Pathogenomics of Culex quinquefasciatus and Meta-Analysis of Infection Responses to Diverse Pathogens

The mosquito Culex quinquefasciatus poses a substantial threat to human and veterinary health as a primary vector of West Nile virus (WNV), the filarial worm Wuchereria bancrofti, and an avian malaria parasite. Comparative phylogenomics revealed an expanded canonical C. quinquefasciatus immune gene...

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Published in:Science (American Association for the Advancement of Science) 2010-10, Vol.330 (6000), p.88-90
Main Authors: Bartholomay, Lyric C, Waterhouse, Robert M, Mayhew, George F, Campbell, Corey L, Michel, Kristin, Zou, Zhen, Ramirez, Jose L, Das, Suchismita, Alvarez, Kanwal, Arensburger, Peter, Bryant, Bart, Chapman, Sinead B, Dong, Yuemei, Erickson, Sara M, Karunaratne, S.H.P. Parakrama, Kokoza, Vladimir, Kodira, Chinnappa D, Pignatelli, Patricia, Shin, Sang Woon, Vanlandingham, Dana L, Atkinson, Peter W, Birren, Bruce, Christophides, George K, Clem, Rollie J, Hemingway, Janet, Higgs, Stephen, Megy, Karine, Ranson, Hilary, Zdobnov, Evgeny M, Raikhel, Alexander S, Christensen, Bruce M, Dimopoulos, George, Muskavitch, Marc A.T
Format: Article
Language:English
Subjects:
Aedes - genetics
Aedes - immunology
Aedes - microbiology
Aedes - parasitology
Aedes aegypti
Animals
Anopheles - genetics
Anopheles - metabolism
Anopheles - microbiology
Anopheles - parasitology
Anopheles gambiae
Arboviruses
Arboviruses - immunology
Arboviruses - pathogenicity
Arboviruses - physiology
Bacteria
Bacteria - immunology
Bacteria - pathogenicity
Biological Evolution
Culex - genetics
Culex - immunology
Culex - microbiology
Culex - parasitology
Culex quinquefasciatus
Ecosystem
Filarioidea - immunology
Filarioidea - pathogenicity
Filarioidea - physiology
Gene Expression Profiling
Gene Expression Regulation
Genes
Genes, Insect
Genomics
Grants
Host-Pathogen Interactions
Immunity
Immunity, Innate - genetics
Immunology
Infections
Insect Vectors - genetics
Insect Vectors - immunology
Insect Vectors - microbiology
Insect Vectors - parasitology
Malaria
Mathematical analysis
Meta-analysis
Mosquitoes
Mosquitos
Oligonucleotide Array Sequence Analysis
Parasites
Pathogens
Phylogenetics
Phylogeny
RNA Interference
Transcription, Genetic
Vectors (mathematics)
Veterinary
West Nile virus
West Nile virus - immunology
West Nile virus - pathogenicity
West Nile virus - physiology
Worms
Wuchereria bancrofti
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Summary:The mosquito Culex quinquefasciatus poses a substantial threat to human and veterinary health as a primary vector of West Nile virus (WNV), the filarial worm Wuchereria bancrofti, and an avian malaria parasite. Comparative phylogenomics revealed an expanded canonical C. quinquefasciatus immune gene repertoire compared with those of Aedes aegypti and Anopheles gambiae. Transcriptomic analysis of C. quinquefasciatus genes responsive to WNV, W. bancrofti, and non-native bacteria facilitated an unprecedented meta-analysis of 25 vector-pathogen interactions involving arboviruses, filarial worms, bacteria, and malaria parasites, revealing common and distinct responses to these pathogen types in three mosquito genera. Our findings provide support for the hypothesis that mosquito-borne pathogens have evolved to evade innate immune responses in three vector mosquito species of major medical importance.
ISSN:0036-8075
1095-9203
1095-9203
DOI:10.1126/science.1193162