TNFα Is Required for Late BRB Breakdown in Diabetic Retinopathy, and Its Inhibition Prevents Leukostasis and Protects Vessels and Neurons from Apoptosis

The absence of TNFα protects against diabetes-associated blood–retinal barrier breakdown, leukostasis, and apoptosis in the retina, making it a good therapeutic target for the prevention of the progressive BRB breakdown, inflammation, and apoptosis associated with diabetic retinopathy.

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Published in:Investigative ophthalmology & visual science 2011-03, Vol.52 (3), p.1336-1344
Main Authors: Huang, Hu, Gandhi, Jarel K., Zhong, Xiufeng, Wei, Yanhong, Gong, Junsong, Duh, Elia J., Vinores, Stanley A.
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Language:English
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container_end_page 1344
container_issue 3
container_start_page 1336
container_title Investigative ophthalmology & visual science
container_volume 52
creator Huang, Hu
Gandhi, Jarel K.
Zhong, Xiufeng
Wei, Yanhong
Gong, Junsong
Duh, Elia J.
Vinores, Stanley A.
description The absence of TNFα protects against diabetes-associated blood–retinal barrier breakdown, leukostasis, and apoptosis in the retina, making it a good therapeutic target for the prevention of the progressive BRB breakdown, inflammation, and apoptosis associated with diabetic retinopathy.
doi_str_mv 10.1167/iovs.10-5768
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title TNFα Is Required for Late BRB Breakdown in Diabetic Retinopathy, and Its Inhibition Prevents Leukostasis and Protects Vessels and Neurons from Apoptosis
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