A Novel miRNA Processing Pathway Independent of Dicer Requires Argonaute2 Catalytic Activity

Dicer is a central enzyme in microRNA (miRNA) processing. We identified a Dicer-independent miRNA biogenesis pathway that uses Argonaute2 (Ago2) slicer catalytic activity. In contrast to other miRNAs, miR-451 levels were refractory to dicer loss of function but were reduced in bhlago2 (maternal-zygo...

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Bibliographic Details

Published in:	Science (American Association for the Advancement of Science) 2010-06, Vol.328 (5986), p.1694-1698
Main Authors:	Cifuentes, Daniel, Xue, Huiling, Taylor, David W., Patnode, Heather, Mishima, Yuichiro, Cheloufi, Sihem, Ma, Enbo, Mane, Shrikant, Hannon, Gregory J., Lawson, Nathan D., Wolfe, Scot A., Giraldez, Antonio J.
Format:	Article
Language:	eng
Subjects:	Animals Argon Argonaute Proteins Biocatalysis Biocompatibility Biological and medical sciences Biomedical materials Catalytic activity Embryo, Nonmammalian - metabolism Embryonic Development Embryos Erythrocytes Erythropoiesis Eukaryotic Initiation Factor-2 - genetics Eukaryotic Initiation Factor-2 - metabolism Fundamental and applied biological sciences. Psychology Humans In vivo testing In vivo tests Messenger RNA MicroRNA MicroRNAs - chemistry MicroRNAs - metabolism Models, Biological Molecular and cellular biology Molecular genetics Morphogenesis Nucleic Acid Conformation Nucleotides Pathways Recombinant Proteins - metabolism Ribonuclease III - metabolism RNA RNA Precursors - metabolism RNA Processing, Post-Transcriptional Sequencing Stem cells Surgical implants Transcription. Transcription factor. Splicing. Rna processing Zebrafish - embryology Zebrafish - genetics Zebrafish - metabolism Zebrafish Proteins - genetics Zebrafish Proteins - metabolism
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