Dual Resistance to Adamantanes and Oseltamivir Among Seasonal Influenza A(H1N1) Viruses: 2008-2010

Two distinct genetic clades of seasonal influenza A(H1N1) viruses have cocirculated in the recent seasons: clade 2B oseltamivir-resistant and adamantane-susceptible viruses, and clade 2C viruses that are resistant to adamantanes and susceptible to oseltamivir. We tested seasonal influenza A(H1N1) vi...

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Bibliographic Details
Published in:The Journal of infectious diseases 2011-01, Vol.203 (1), p.13-17
Main Authors: Sheu, Tiffany G., Fry, Alicia M., Garten, Rebecca J., Deyde, Varough M., Shwe, Thein, Bullion, Lesley, Peebles, Patrick J., Li, Yan, Klimov, Alexander I., Gubareva, Larisa V.
Format: Article
Language:English
Subjects:
Adamantane - pharmacology
Amino Acid Substitution - genetics
Antiviral Agents - pharmacology
Antivirals
Biological and medical sciences
Drug Resistance, Multiple, Viral
Fundamental and applied biological sciences. Psychology
Genetic mutation
Genome, Viral
Genomes
Genotype
Genotypes
H1N1 subtype influenza A virus
Humans
Infectious diseases
Influenza A virus
Influenza A Virus, H1N1 Subtype - drug effects
Influenza A Virus, H1N1 Subtype - genetics
Influenza A Virus, H1N1 Subtype - isolation & purification
Influenza, Human - epidemiology
Influenza, Human - virology
Major and Brief Reports
Medical sciences
Microbiology
Miscellaneous
Mutation, Missense
Neuraminidase - genetics
Orthomyxoviridae
Oseltamivir - pharmacology
Public health
RNA, Viral - genetics
Surveillance
Viral Matrix Proteins - genetics
Viral Proteins - genetics
Virology
Viruses
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Summary:Two distinct genetic clades of seasonal influenza A(H1N1) viruses have cocirculated in the recent seasons: clade 2B oseltamivir-resistant and adamantane-susceptible viruses, and clade 2C viruses that are resistant to adamantanes and susceptible to oseltamivir. We tested seasonal influenza A(H1N1) viruses collected in 2008-2010 from the United States and globally for resistance to antivirals approved by the Food and Drug Administration. We report 28 viruses with both adamantane and oseltamivir (dual) resistance from 5 countries belonging to 4 distinct genotypes. Because of limited options for antiviral treatment, emergence of dual-resistant influenza viruses poses a public health concern, and their circulation needs to be closely monitored.
ISSN:0022-1899
1537-6613
1537-6613
0022-1899
DOI:10.1093/infdis/jiq005