Role of angiotensin II type I receptor agonistic autoantibodies (AT1-AA) in preeclampsia

Despite being one of the leading causes of maternal death and a major contributor of maternal and perinatal morbidity, the mechanisms responsible for the pathogenesis of preeclampsia are unclear. One important initiating event in preeclampsia is thought to be reduced placental perfusion leading to t...

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Bibliographic Details
Published in:Current opinion in pharmacology 2011-04, Vol.11 (2), p.175-179
Main Authors: LaMarca, Babbette, Wallace, Kedra, Granger, Joey
Format: Article
Language:English
Subjects:
Autoantibodies - blood
Autoantibodies - physiology
Female
Humans
Hypertension, Pregnancy-Induced - etiology
Internal Medicine
Ischemia - immunology
Medical Education
Placenta - blood supply
Pre-Eclampsia - etiology
Pre-Eclampsia - immunology
Pregnancy
Receptor, Angiotensin, Type 1 - immunology
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Summary:Despite being one of the leading causes of maternal death and a major contributor of maternal and perinatal morbidity, the mechanisms responsible for the pathogenesis of preeclampsia are unclear. One important initiating event in preeclampsia is thought to be reduced placental perfusion leading to the production of a variety of factors that cause widespread dysfunction of the maternal vasculature. The major objective of this review is to discuss the potential role of a novel agonistic autoantibody to the angiotensin II type I receptor (AT1-AA) in mediating hypertension during pregnancy. Although animal studies suggest that increasing plasma AT1-AA concentration in pregnant rats to levels observed in preeclamptic women or placental ischemic rats result in significant increases in arterial pressure, the quantitative importance of AT1-AA in the pathophysiology of preeclampsia in humans has yet to be fully elucidated.
ISSN:1471-4892
1471-4973
DOI:10.1016/j.coph.2011.01.003