Marked Reduction in Prevalence of Malaria Parasitemia and Anemia in HIV-Infected Pregnant Women Taking Cotrimoxazole With Or Without Sulfadoxine-Pyrimethamine Intermittent Preventive Therapy during Pregnancy in Malawi

Background. Effectiveness of cotrimoxazole (CTX) compared with sulfadoxine-pyrimethamine (SP) intermittent-preventive-therapy (IPTp) for malaria in HIV-infected pregnant women is unknown. We examined effectiveness of CTX with or without SP-IPTp versus SP-IPTp at reducing malaria parasitemia and anem...

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Bibliographic Details
Published in:The Journal of infectious diseases 2011-02, Vol.203 (4), p.464-472
Main Authors: Kapito-Tembo, Atupele, Meshnick, Steven R., van Hensbroek, Michaël Boele, Phiri, Kamija, Fitzgerald, Margaret, Mwapasa, Victor
Format: Article
Language:English
Subjects:
Adolescent
Adult
Anemia
Anemia - epidemiology
Anemia - prevention & control
Antimalarials
Antimalarials - therapeutic use
Biological and medical sciences
Chemoprevention - methods
Cross-Sectional Studies
Drug Combinations
Female
Fundamental and applied biological sciences. Psychology
Hemoglobins
HIV
HIV Infections - complications
HIV/AIDS
Human immunodeficiency virus
Human protozoal diseases
Human viral diseases
Humans
Infections
Infectious diseases
Major and Brief Reports
Malaria
Malaria - complications
Malaria - epidemiology
Malaria - parasitology
Malaria - prevention & control
Malawi - epidemiology
Medical sciences
Microbiology
Middle Aged
Parasitemia
Parasitemia - epidemiology
Parasitemia - prevention & control
Parasites
Parasitic diseases
Pregnancy
Pregnancy Complications, Infectious - epidemiology
Prevalence
Protozoal diseases
Pyrimethamine - therapeutic use
Sulfadoxine - therapeutic use
Treatment Outcome
Trimethoprim, Sulfamethoxazole Drug Combination - therapeutic use
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Women
Young Adult
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Summary:Background. Effectiveness of cotrimoxazole (CTX) compared with sulfadoxine-pyrimethamine (SP) intermittent-preventive-therapy (IPTp) for malaria in HIV-infected pregnant women is unknown. We examined effectiveness of CTX with or without SP-IPTp versus SP-IPTp at reducing malaria parasitemia and anemia. Methods. From 2005 to 2009, we conducted a cross-sectional study of HIV-infected pregnant women at Thyolo Hospital, Malawi. Blood was tested for malaria parasitemia and anemia (hemoglobin
ISSN:0022-1899
1537-6613
1537-6613
0022-1899
DOI:10.1093/infdis/jiq072