SNP rs6457327 in the HLA region on chromosome 6p is predictive of the transformation of follicular lymphoma

Inherited risk determinants for follicular lymphoma (FL) have recently been described in the immune gene-rich human leukocyte antigen region on chromosome 6p. The known importance of host immune response to FL survival led us to evaluate these germline factors in FL outcome. We confirm the associati...

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Bibliographic Details
Published in:Blood 2011-03, Vol.117 (11), p.3147-3150
Main Authors: Wrench, David, Leighton, Pamela, Skibola, Christine F., Conde, Lucia, Cazier, Jean-Baptiste, Matthews, Janet, Iqbal, Sameena, Carlotti, Emanuela, Bödör, Csaba, Montoto, Silvia, Calaminici, Maria, Gribben, John G., Lister, T. Andrew, Fitzgibbon, Jude
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cell Transformation, Neoplastic - genetics
Cell Transformation, Neoplastic - pathology
Chromosomes, Human, Pair 6 - genetics
Hematologic and hematopoietic diseases
HLA Antigens - genetics
Humans
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Lymphoid Neoplasia
Lymphoma, Follicular - genetics
Lymphoma, Follicular - pathology
Medical sciences
Middle Aged
Polymorphism, Single Nucleotide - genetics
Risk Factors
Time Factors
United Kingdom
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Summary:Inherited risk determinants for follicular lymphoma (FL) have recently been described in the immune gene-rich human leukocyte antigen region on chromosome 6p. The known importance of host immune response to FL survival led us to evaluate these germline factors in FL outcome. We confirm the association of single nucleotide polymorphisms rs10484561 (P = 3.5 × 10−9) and rs6457327 (P = .008) with risk of FL and demonstrate that rs6457327 predicts both time to (P = .02) and risk of (P < .01) FL transformation independently of clinical variables, including the Follicular Lymphoma International Prognostic Index.
ISSN:0006-4971
1528-0020
DOI:10.1182/blood-2010-10-315382