Effect of autoimmune thyroid disease in older euthyroid infertile woman during the first 35 days of an IVF cycle

In this case-control study of euthyroid first-cycle IVF patients ≥38 years old with singleton baby, miscarriage, biochemical pregnancy, and no pregnancy outcomes from 2005–2008, we assayed frozen serum for autoimmune thyroid disease (AITD) and thyroid function at cycle start, trigger, and 4 and 5 we...

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Bibliographic Details
Published in:Fertility and sterility 2011-03, Vol.95 (3), p.1178-1181
Main Authors: Reh, Andrea, M.D, Chaudhry, Sonal, M.D, Mendelsohn, Felicia, M.D, Im, Shelly, M.D, Rolnitzky, Linda, M.S, Amarosa, Alana, M.D, Levitz, Mortimer, Ph.D, Srinivasa, Suman, M.D, Krey, Lewis, Ph.D, Berkeley, Alan S., M.D, Grifo, James A., M.D., Ph.D, Danoff, Ann, M.D
Format: Article
Language:English
Subjects:
abortion (animals)
Abortion, Spontaneous - epidemiology
Adult
Biological and medical sciences
blood serum
Case-Control Studies
Diseases of mother, fetus and pregnancy
Endocrinopathies
Female
Fertilization in Vitro - statistics & numerical data
Gynecology. Andrology. Obstetrics
Humans
hypothyroidism
Hypothyroidism - epidemiology
in vitro fertilization
infertility
Infertility, Female - epidemiology
Infertility, Female - therapy
Internal Medicine
IVF
Maternal Age
Medical sciences
miscarriage
Non tumoral diseases. Target tissue resistance. Benign neoplasms
Obstetrics and Gynecology
patients
Pregnancy
pregnancy outcome
Pregnancy Outcome - epidemiology
Pregnancy. Fetus. Placenta
Prevalence
subclinical hypothyroidism
thyroglobulin antibody
Thyroid autoimmunity
thyroid function
Thyroid Gland - physiology
thyroid peroxidase antibody
Thyroid. Thyroid axis (diseases)
Thyroiditis, Autoimmune - epidemiology
thyrotropin
women
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Summary:In this case-control study of euthyroid first-cycle IVF patients ≥38 years old with singleton baby, miscarriage, biochemical pregnancy, and no pregnancy outcomes from 2005–2008, we assayed frozen serum for autoimmune thyroid disease (AITD) and thyroid function at cycle start, trigger, and 4 and 5 weeks’ gestation. AITD prevalence in older infertile women was similar across clinical outcomes, and although AITD was associated with a higher baseline TSH, TSH remained within acceptable ranges, suggesting that T4 supplementation may not affect maternal outcomes in older euthyroid AITD patients through 5 weeks gestation.
ISSN:0015-0282
1556-5653
DOI:10.1016/j.fertnstert.2010.09.053