Immunogenicity of Vi capsular polysaccharide vaccine evaluated for three years in Korea

The immunogenicity of a single dose of Salmonella typhi(S.typhi) Vi capsular polysaccharide(CPS) vaccine was evaluated before, and at 1, 3, 12, and 36 months after vaccination. Eighty-five adults(20-28 years of age) and sixty-four children(8-16 years of age) received a single dose of 25 micrograms V...

Full description

Saved in:
Bibliographic Details
Published in:Journal of Korean medical science 1995-10, Vol.10 (5), p.314-317
Main Authors: Kim, Y R, Yoo, J H, Hur, J K, Kang, J H, Shin, W S, Kang, M W
Format: Article
Language:English
Subjects:
Adolescent
Adult
Antibodies, Bacterial - blood
Antigens, Bacterial - immunology
Child
Evaluation Studies as Topic
Humans
Polysaccharides, Bacterial - immunology
Salmonella typhi - immunology
Typhoid Fever - prevention & control
Typhoid-Paratyphoid Vaccines - adverse effects
Typhoid-Paratyphoid Vaccines - immunology
Typhoid-Paratyphoid Vaccines - therapeutic use
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The immunogenicity of a single dose of Salmonella typhi(S.typhi) Vi capsular polysaccharide(CPS) vaccine was evaluated before, and at 1, 3, 12, and 36 months after vaccination. Eighty-five adults(20-28 years of age) and sixty-four children(8-16 years of age) received a single dose of 25 micrograms Vi CPS vaccine intramuscularly, and antibody titers to Vi CPS were measured by passive hemagglutination. Of 149 vaccinees, 138(92.6%) showed seroconversion at 1 month after vaccination, and then 138 out of 141(97.9%) did at 3 months. Of 137 vaccinees, 116(84.7%) maintained a persistent rise in Vi antibody titer 12 months after vaccination, and 55 out of 100(55.0%) had a 4-fold or greater rise at 36 months. No significant adverse reactions were observed. Booster injection may be needed 3-5 years after vaccination.
ISSN:1011-8934
1598-6357
DOI:10.3346/jkms.1995.10.5.314