Methylprednisolone pulse therapy combined with mizoribine following tonsillectomy for immunoglobulin A nephropathy: clinical remission rate, steroid sparing effect, and maintenance of renal function

Background The long-term prognosis of immunoglobulin A nephropathy (IgAN) is reportedly poor. In Japan, tonsillectomy-steroid pulse therapy has frequently been used for treatment of early IgAN, with favorable outcomes. However, steroid usage is sometimes limited due to adverse reactions. To reduce t...

Full description

Saved in:
Bibliographic Details
Published in:Clinical and experimental nephrology 2011-02, Vol.15 (1), p.73-78
Main Authors: Kaneko, Tomohiro, Hirama, Akio, Ueda, Kae, Fujino, Teppei, Utsumi, Koichi, Iino, Yasuhiko, Katayama, Yasuo
Format: Article
Language:English
Subjects:
Adolescent
Adult
Epidermal growth factor receptors
Female
Glomerular Filtration Rate
Glomerulonephritis, IGA - drug therapy
Glomerulonephritis, IGA - physiopathology
Glomerulonephritis, IGA - surgery
Glucocorticoids - therapeutic use
Humans
Immunoglobulin A
Immunosuppressive Agents - therapeutic use
Intravenous administration
Japan
Kidney - physiology
Kidney diseases
Kidney Failure, Chronic - drug therapy
Kidney Failure, Chronic - physiopathology
Kidney Function Tests
Male
Medicine
Medicine & Public Health
methylprednisolone
Methylprednisolone - administration & dosage
Methylprednisolone - therapeutic use
Middle Aged
Nephrology
Nephropathy
Original
Original Article
Prednisolone
Prognosis
Pulse Therapy, Drug
Remission
Remission Induction
Renal function
Retrospective Studies
Ribonucleosides - therapeutic use
Side effects
Steroid hormones
Tonsillectomy
Treatment Outcome
Urology
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background The long-term prognosis of immunoglobulin A nephropathy (IgAN) is reportedly poor. In Japan, tonsillectomy-steroid pulse therapy has frequently been used for treatment of early IgAN, with favorable outcomes. However, steroid usage is sometimes limited due to adverse reactions. To reduce the total dose of steroids, we have been using mizoribine (MZR) in combination with tonsillectomy-steroid pulse therapy since 2004. Here we report a retrospective evaluation of our protocol outcome. Methods Forty-two patients aged
ISSN:1342-1751
1437-7799
DOI:10.1007/s10157-010-0356-2