Changes of genetic apolipoprotein phenotypes caused by liver transplantation. Implications for apolipoprotein synthesis

Liver transplantation provides a unique opportunity to investigate the contribution in vivo of the liver to the synthesis and degradation of genetically polymorphic plasma proteins. We have determined the genetic polymorphisms plasma proteins. We have determined the genetic polymorphisms of apo A-IV...

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Bibliographic Details
Published in:The Journal of clinical investigation 1989-01, Vol.83 (1), p.137-142
Main Authors: Kraft, H G, Menzel, H J, Hoppichler, F, Vogel, W, Utermann, G
Format: Article
Language:English
Subjects:
Adolescent
Adult
Apolipoproteins - biosynthesis
Apolipoproteins - genetics
Apolipoproteins A - blood
Apolipoproteins A - genetics
Apolipoproteins E - blood
Apolipoproteins E - genetics
Female
Humans
Lipoprotein(a)
Lipoproteins - blood
Lipoproteins - genetics
Liver Transplantation
Male
Middle Aged
Phenotype
Polymorphism, Genetic
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Summary:Liver transplantation provides a unique opportunity to investigate the contribution in vivo of the liver to the synthesis and degradation of genetically polymorphic plasma proteins. We have determined the genetic polymorphisms plasma proteins. We have determined the genetic polymorphisms of apo A-IV, apo E, and of the Lp(a) glycoprotein (apo (a] in the plasma of subjects undergoing liver transplantation and in respective organ donors. The results show that in humans, greater than 90% of the plasma apo E and virtually all apo (a) are liver derived, whereas this organ does not significantly contribute to plasma apo A-IV levels.
ISSN:0021-9738
1558-8238
DOI:10.1172/jci113849