Evaluation of the naturally acquired antibody immune response to the Pv200L N-terminal fragment of Plasmodium vivax merozoite surface protein-1 in four areas of the Amazon Region of Brazil

Frequency and levels of IgG antibodies to an N-terminal fragment of the Plasmodium vivax MSP-1 (Pv200L) protein, in individuals naturally exposed to malaria in four endemic areas of Brazil, were evaluated by enzyme-linked immunosorbent assay. Plasma samples of 261 P. vivax-infected individuals from...

Full description

Saved in:
Bibliographic Details
Published in:The American journal of tropical medicine and hygiene 2011-02, Vol.84 (2 Suppl), p.58-63
Main Authors: Storti-Melo, Luciane M, Souza-Neiras, Wanessa C, Cassiano, Gustavo C, Taveira, Leonardo C, Cordeiro, Antônio J, Couto, Vanja S C A, Póvoa, Marinete M, Cunha, Maristela G, Echeverry, Diana M, Rossit, Andréa R B, Arévalo-Herrera, Myriam, Herrera, Sócrates, Machado, Ricardo L D
Format: Article
Language:English
Subjects:
Animals
Antibodies, Protozoan - biosynthesis
Antibodies, Protozoan - blood
Brazil - epidemiology
Enzyme-Linked Immunosorbent Assay
Humans
Immunoglobulin G - biosynthesis
Immunoglobulin G - blood
Malaria, Vivax - epidemiology
Malaria, Vivax - immunology
Malaria, Vivax - parasitology
Merozoite Surface Protein 1 - chemistry
Merozoite Surface Protein 1 - immunology
Plasmodium vivax
Plasmodium vivax - immunology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Frequency and levels of IgG antibodies to an N-terminal fragment of the Plasmodium vivax MSP-1 (Pv200L) protein, in individuals naturally exposed to malaria in four endemic areas of Brazil, were evaluated by enzyme-linked immunosorbent assay. Plasma samples of 261 P. vivax-infected individuals from communities of Macapá, Novo Repartimento, Porto Velho, and Plácido de Castro in the Amazonian region with different malaria transmission intensities. A high mean number of studied individuals (89.3%) presented with antibodies to the Pv200L that correlated with the number of previous malaria infections; there were significant differences in the frequency of the responders (71.9-98.7) and in the antibody levels (1:200-1:51,200) among the four study areas. Results of this study provide evidence that Pv200L is a naturally immunogenic fragment of the PvMSP-1 and is associated with the degree of exposure to parasites. The fine specificity of antibodies to Pv200L is currently being assessed.
ISSN:0002-9637
1476-1645
DOI:10.4269/ajtmh.2011.10-0044