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Correlates of Coronary Artery Calcified Plaque in Blacks and Whites with Type 2 Diabetes
Purpose To examine whether the relationship between cardiovascular disease risk factors and coronary artery calcification (CAC) is modified by race among those with diabetes. Methods Data were pooled data from three studies (Multi-Ethnic Study of Atherosclerosis, Family Heart Study, Diabetes Heart S...
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| Published in: | Annals of epidemiology 2011, Vol.21 (1), p.34-41 |
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| creator | Wagenknecht, Lynne E., DrPH Divers, Jasmin, PhD Bertoni, Alain G., MD, MPH Langefeld, Carl D., PhD Carr, J. Jeffrey, MD, MS Bowden, Donald W., PhD Elbein, Steven C., MD Shea, Steven, MD, MS Lewis, Cora E., MD, MSPH Freedman, Barry I., MD |
| description | Purpose To examine whether the relationship between cardiovascular disease risk factors and coronary artery calcification (CAC) is modified by race among those with diabetes. Methods Data were pooled data from three studies (Multi-Ethnic Study of Atherosclerosis, Family Heart Study, Diabetes Heart Study) for a total of 835 blacks and 1122 whites with diabetes. CAC was quantified by cardiac computed tomography and risk factors were obtained using standard methods. Regression models examined the relationship between risk factors and presence and quantity of CAC. Results The average age of the cohort was 60 years; 57% were women. Presence of CAC was lower in blacks compared to whites (odds ratio = 0.22 for men, 0.57 for women, p |
| doi_str_mv | 10.1016/j.annepidem.2010.10.007 |
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| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3026318</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1047279710003625</els_id><sourcerecordid>853487454</sourcerecordid><originalsourceid>FETCH-LOGICAL-c561t-8d03de3105e9e86f5164cde3ee7e346205370b3813df60b3c4e2c273840708c53</originalsourceid><addsrcrecordid>eNqNUstuUzEQtRAVfcAvgHesbvDj-pFNpRCeUqUiUQQ7y_GdS5w6dmrfFOXv60vaCNiU1YzPnDn2-AxCryiZUELlm9XExggb38F6wshvdEKIeoJOqFa8YUKLpzUnrWqYmqpjdFrKilSGVuwZOmaUcsKlOkE_5ilnCHaAglOP6ylFm3d4lgeoYW6D872HDn8J9mYL2Ef8Nlh3XbCNHf6-9GPjLz8s8dVuA5jhd94uoILP0VFvQ4EX9_EMffvw_mr-qbm4_Ph5PrtonJB0aHRHeAecEgFT0LIXVLauAgAKeCsZEVyRBdeUd72siWuBOaa4boki2gl-hs73upvtYg2dgzhkG8wm-3WdwyTrzd-V6JfmZ7o1nDDJqa4Cr-8FcqoTlsGsfXEQgo2QtsVowVutWtE-zqSSazHl08pUe6bLqZQM_eE9lJjRQLMyBwPNaOBYqPbUzpd_jnPoe3CsEmZ7AtRPvfWQTXEeooPOZ3CD6ZL_j0vO_9FwwUfvbLiGHZRV2uZYPTPUFGaI-Tru0bhGtG4Ql0zwOxEoxQI</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>816385939</pqid></control><display><type>article</type><title>Correlates of Coronary Artery Calcified Plaque in Blacks and Whites with Type 2 Diabetes</title><source>ScienceDirect Journals</source><creator>Wagenknecht, Lynne E., DrPH ; Divers, Jasmin, PhD ; Bertoni, Alain G., MD, MPH ; Langefeld, Carl D., PhD ; Carr, J. Jeffrey, MD, MS ; Bowden, Donald W., PhD ; Elbein, Steven C., MD ; Shea, Steven, MD, MS ; Lewis, Cora E., MD, MSPH ; Freedman, Barry I., MD</creator><creatorcontrib>Wagenknecht, Lynne E., DrPH ; Divers, Jasmin, PhD ; Bertoni, Alain G., MD, MPH ; Langefeld, Carl D., PhD ; Carr, J. Jeffrey, MD, MS ; Bowden, Donald W., PhD ; Elbein, Steven C., MD ; Shea, Steven, MD, MS ; Lewis, Cora E., MD, MSPH ; Freedman, Barry I., MD</creatorcontrib><description>Purpose To examine whether the relationship between cardiovascular disease risk factors and coronary artery calcification (CAC) is modified by race among those with diabetes. Methods Data were pooled data from three studies (Multi-Ethnic Study of Atherosclerosis, Family Heart Study, Diabetes Heart Study) for a total of 835 blacks and 1122 whites with diabetes. CAC was quantified by cardiac computed tomography and risk factors were obtained using standard methods. Regression models examined the relationship between risk factors and presence and quantity of CAC. Results The average age of the cohort was 60 years; 57% were women. Presence of CAC was lower in blacks compared to whites (odds ratio = 0.22 for men, 0.57 for women, p <0.01). Hemoglobin A1c, duration of diabetes, low-density lipoprotein, smoking, and body mass index were independently associated with presence of CAC; high-density lipoprotein, triglycerides, and C-reactive protein were not. Race did not modify these associations. Adjustment for multiple risk factors did not explain the race disparity in CAC. Conclusions CAC was reduced in blacks compared to whites in persons with diabetes. This effect was most pronounced in men. The relationship between risk factors and CAC did not differ between races. Racial differences in CAC are likely due to unmeasured risk factors and/or genetic susceptibility.</description><identifier>ISSN: 1047-2797</identifier><identifier>EISSN: 1873-2585</identifier><identifier>DOI: 10.1016/j.annepidem.2010.10.007</identifier><identifier>PMID: 21130367</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; African-Americans ; Aged ; Aged, 80 and over ; Calcinosis - epidemiology ; Calcinosis - ethnology ; Cohort Studies ; Coronary Artery Disease ; Coronary Artery Disease - epidemiology ; Coronary Artery Disease - ethnology ; Diabetes Mellitus ; Diabetes Mellitus, Type 2 - epidemiology ; Diabetes Mellitus, Type 2 - ethnology ; Epidemiology ; Female ; Genetic Predisposition to Disease ; Health Status Disparities ; Humans ; Internal Medicine ; Male ; Middle Aged ; Risk Factors ; Tomography, X-Ray Computed</subject><ispartof>Annals of epidemiology, 2011, Vol.21 (1), p.34-41</ispartof><rights>Elsevier Inc.</rights><rights>2011 Elsevier Inc.</rights><rights>Copyright © 2011 Elsevier Inc. All rights reserved.</rights><rights>2010 Elsevier Inc. All rights reserved. 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c561t-8d03de3105e9e86f5164cde3ee7e346205370b3813df60b3c4e2c273840708c53</citedby><cites>FETCH-LOGICAL-c561t-8d03de3105e9e86f5164cde3ee7e346205370b3813df60b3c4e2c273840708c53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,315,786,790,891,4043,27956,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21130367$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wagenknecht, Lynne E., DrPH</creatorcontrib><creatorcontrib>Divers, Jasmin, PhD</creatorcontrib><creatorcontrib>Bertoni, Alain G., MD, MPH</creatorcontrib><creatorcontrib>Langefeld, Carl D., PhD</creatorcontrib><creatorcontrib>Carr, J. Jeffrey, MD, MS</creatorcontrib><creatorcontrib>Bowden, Donald W., PhD</creatorcontrib><creatorcontrib>Elbein, Steven C., MD</creatorcontrib><creatorcontrib>Shea, Steven, MD, MS</creatorcontrib><creatorcontrib>Lewis, Cora E., MD, MSPH</creatorcontrib><creatorcontrib>Freedman, Barry I., MD</creatorcontrib><title>Correlates of Coronary Artery Calcified Plaque in Blacks and Whites with Type 2 Diabetes</title><title>Annals of epidemiology</title><addtitle>Ann Epidemiol</addtitle><description>Purpose To examine whether the relationship between cardiovascular disease risk factors and coronary artery calcification (CAC) is modified by race among those with diabetes. Methods Data were pooled data from three studies (Multi-Ethnic Study of Atherosclerosis, Family Heart Study, Diabetes Heart Study) for a total of 835 blacks and 1122 whites with diabetes. CAC was quantified by cardiac computed tomography and risk factors were obtained using standard methods. Regression models examined the relationship between risk factors and presence and quantity of CAC. Results The average age of the cohort was 60 years; 57% were women. Presence of CAC was lower in blacks compared to whites (odds ratio = 0.22 for men, 0.57 for women, p <0.01). Hemoglobin A1c, duration of diabetes, low-density lipoprotein, smoking, and body mass index were independently associated with presence of CAC; high-density lipoprotein, triglycerides, and C-reactive protein were not. Race did not modify these associations. Adjustment for multiple risk factors did not explain the race disparity in CAC. Conclusions CAC was reduced in blacks compared to whites in persons with diabetes. This effect was most pronounced in men. The relationship between risk factors and CAC did not differ between races. Racial differences in CAC are likely due to unmeasured risk factors and/or genetic susceptibility.</description><subject>Adult</subject><subject>African-Americans</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Calcinosis - epidemiology</subject><subject>Calcinosis - ethnology</subject><subject>Cohort Studies</subject><subject>Coronary Artery Disease</subject><subject>Coronary Artery Disease - epidemiology</subject><subject>Coronary Artery Disease - ethnology</subject><subject>Diabetes Mellitus</subject><subject>Diabetes Mellitus, Type 2 - epidemiology</subject><subject>Diabetes Mellitus, Type 2 - ethnology</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Genetic Predisposition to Disease</subject><subject>Health Status Disparities</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Risk Factors</subject><subject>Tomography, X-Ray Computed</subject><issn>1047-2797</issn><issn>1873-2585</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNqNUstuUzEQtRAVfcAvgHesbvDj-pFNpRCeUqUiUQQ7y_GdS5w6dmrfFOXv60vaCNiU1YzPnDn2-AxCryiZUELlm9XExggb38F6wshvdEKIeoJOqFa8YUKLpzUnrWqYmqpjdFrKilSGVuwZOmaUcsKlOkE_5ilnCHaAglOP6ylFm3d4lgeoYW6D872HDn8J9mYL2Ef8Nlh3XbCNHf6-9GPjLz8s8dVuA5jhd94uoILP0VFvQ4EX9_EMffvw_mr-qbm4_Ph5PrtonJB0aHRHeAecEgFT0LIXVLauAgAKeCsZEVyRBdeUd72siWuBOaa4boki2gl-hs73upvtYg2dgzhkG8wm-3WdwyTrzd-V6JfmZ7o1nDDJqa4Cr-8FcqoTlsGsfXEQgo2QtsVowVutWtE-zqSSazHl08pUe6bLqZQM_eE9lJjRQLMyBwPNaOBYqPbUzpd_jnPoe3CsEmZ7AtRPvfWQTXEeooPOZ3CD6ZL_j0vO_9FwwUfvbLiGHZRV2uZYPTPUFGaI-Tru0bhGtG4Ql0zwOxEoxQI</recordid><startdate>2011</startdate><enddate>2011</enddate><creator>Wagenknecht, Lynne E., DrPH</creator><creator>Divers, Jasmin, PhD</creator><creator>Bertoni, Alain G., MD, MPH</creator><creator>Langefeld, Carl D., PhD</creator><creator>Carr, J. Jeffrey, MD, MS</creator><creator>Bowden, Donald W., PhD</creator><creator>Elbein, Steven C., MD</creator><creator>Shea, Steven, MD, MS</creator><creator>Lewis, Cora E., MD, MSPH</creator><creator>Freedman, Barry I., MD</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QP</scope><scope>7U1</scope><scope>7U2</scope><scope>C1K</scope><scope>5PM</scope></search><sort><creationdate>2011</creationdate><title>Correlates of Coronary Artery Calcified Plaque in Blacks and Whites with Type 2 Diabetes</title><author>Wagenknecht, Lynne E., DrPH ; Divers, Jasmin, PhD ; Bertoni, Alain G., MD, MPH ; Langefeld, Carl D., PhD ; Carr, J. Jeffrey, MD, MS ; Bowden, Donald W., PhD ; Elbein, Steven C., MD ; Shea, Steven, MD, MS ; Lewis, Cora E., MD, MSPH ; Freedman, Barry I., MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c561t-8d03de3105e9e86f5164cde3ee7e346205370b3813df60b3c4e2c273840708c53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>African-Americans</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Calcinosis - epidemiology</topic><topic>Calcinosis - ethnology</topic><topic>Cohort Studies</topic><topic>Coronary Artery Disease</topic><topic>Coronary Artery Disease - epidemiology</topic><topic>Coronary Artery Disease - ethnology</topic><topic>Diabetes Mellitus</topic><topic>Diabetes Mellitus, Type 2 - epidemiology</topic><topic>Diabetes Mellitus, Type 2 - ethnology</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Genetic Predisposition to Disease</topic><topic>Health Status Disparities</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Risk Factors</topic><topic>Tomography, X-Ray Computed</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wagenknecht, Lynne E., DrPH</creatorcontrib><creatorcontrib>Divers, Jasmin, PhD</creatorcontrib><creatorcontrib>Bertoni, Alain G., MD, MPH</creatorcontrib><creatorcontrib>Langefeld, Carl D., PhD</creatorcontrib><creatorcontrib>Carr, J. Jeffrey, MD, MS</creatorcontrib><creatorcontrib>Bowden, Donald W., PhD</creatorcontrib><creatorcontrib>Elbein, Steven C., MD</creatorcontrib><creatorcontrib>Shea, Steven, MD, MS</creatorcontrib><creatorcontrib>Lewis, Cora E., MD, MSPH</creatorcontrib><creatorcontrib>Freedman, Barry I., MD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Annals of epidemiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wagenknecht, Lynne E., DrPH</au><au>Divers, Jasmin, PhD</au><au>Bertoni, Alain G., MD, MPH</au><au>Langefeld, Carl D., PhD</au><au>Carr, J. Jeffrey, MD, MS</au><au>Bowden, Donald W., PhD</au><au>Elbein, Steven C., MD</au><au>Shea, Steven, MD, MS</au><au>Lewis, Cora E., MD, MSPH</au><au>Freedman, Barry I., MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Correlates of Coronary Artery Calcified Plaque in Blacks and Whites with Type 2 Diabetes</atitle><jtitle>Annals of epidemiology</jtitle><addtitle>Ann Epidemiol</addtitle><date>2011</date><risdate>2011</risdate><volume>21</volume><issue>1</issue><spage>34</spage><epage>41</epage><pages>34-41</pages><issn>1047-2797</issn><eissn>1873-2585</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><notes>ObjectType-Article-2</notes><notes>ObjectType-Feature-1</notes><abstract>Purpose To examine whether the relationship between cardiovascular disease risk factors and coronary artery calcification (CAC) is modified by race among those with diabetes. Methods Data were pooled data from three studies (Multi-Ethnic Study of Atherosclerosis, Family Heart Study, Diabetes Heart Study) for a total of 835 blacks and 1122 whites with diabetes. CAC was quantified by cardiac computed tomography and risk factors were obtained using standard methods. Regression models examined the relationship between risk factors and presence and quantity of CAC. Results The average age of the cohort was 60 years; 57% were women. Presence of CAC was lower in blacks compared to whites (odds ratio = 0.22 for men, 0.57 for women, p <0.01). Hemoglobin A1c, duration of diabetes, low-density lipoprotein, smoking, and body mass index were independently associated with presence of CAC; high-density lipoprotein, triglycerides, and C-reactive protein were not. Race did not modify these associations. Adjustment for multiple risk factors did not explain the race disparity in CAC. Conclusions CAC was reduced in blacks compared to whites in persons with diabetes. This effect was most pronounced in men. The relationship between risk factors and CAC did not differ between races. Racial differences in CAC are likely due to unmeasured risk factors and/or genetic susceptibility.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>21130367</pmid><doi>10.1016/j.annepidem.2010.10.007</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Annals of epidemiology, 2011, Vol.21 (1), p.34-41 |
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| subjects | Adult African-Americans Aged Aged, 80 and over Calcinosis - epidemiology Calcinosis - ethnology Cohort Studies Coronary Artery Disease Coronary Artery Disease - epidemiology Coronary Artery Disease - ethnology Diabetes Mellitus Diabetes Mellitus, Type 2 - epidemiology Diabetes Mellitus, Type 2 - ethnology Epidemiology Female Genetic Predisposition to Disease Health Status Disparities Humans Internal Medicine Male Middle Aged Risk Factors Tomography, X-Ray Computed |
| title | Correlates of Coronary Artery Calcified Plaque in Blacks and Whites with Type 2 Diabetes |
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