Correlates of Coronary Artery Calcified Plaque in Blacks and Whites with Type 2 Diabetes

Purpose To examine whether the relationship between cardiovascular disease risk factors and coronary artery calcification (CAC) is modified by race among those with diabetes. Methods Data were pooled data from three studies (Multi-Ethnic Study of Atherosclerosis, Family Heart Study, Diabetes Heart S...

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Bibliographic Details
Published in:Annals of epidemiology 2011, Vol.21 (1), p.34-41
Main Authors: Wagenknecht, Lynne E., DrPH, Divers, Jasmin, PhD, Bertoni, Alain G., MD, MPH, Langefeld, Carl D., PhD, Carr, J. Jeffrey, MD, MS, Bowden, Donald W., PhD, Elbein, Steven C., MD, Shea, Steven, MD, MS, Lewis, Cora E., MD, MSPH, Freedman, Barry I., MD
Format: Article
Language:English
Subjects:
Adult
African-Americans
Aged
Aged, 80 and over
Calcinosis - epidemiology
Calcinosis - ethnology
Cohort Studies
Coronary Artery Disease
Coronary Artery Disease - epidemiology
Coronary Artery Disease - ethnology
Diabetes Mellitus
Diabetes Mellitus, Type 2 - epidemiology
Diabetes Mellitus, Type 2 - ethnology
Epidemiology
Female
Genetic Predisposition to Disease
Health Status Disparities
Humans
Internal Medicine
Male
Middle Aged
Risk Factors
Tomography, X-Ray Computed
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Summary:Purpose To examine whether the relationship between cardiovascular disease risk factors and coronary artery calcification (CAC) is modified by race among those with diabetes. Methods Data were pooled data from three studies (Multi-Ethnic Study of Atherosclerosis, Family Heart Study, Diabetes Heart Study) for a total of 835 blacks and 1122 whites with diabetes. CAC was quantified by cardiac computed tomography and risk factors were obtained using standard methods. Regression models examined the relationship between risk factors and presence and quantity of CAC. Results The average age of the cohort was 60 years; 57% were women. Presence of CAC was lower in blacks compared to whites (odds ratio = 0.22 for men, 0.57 for women, p
ISSN:1047-2797
1873-2585
DOI:10.1016/j.annepidem.2010.10.007