CXCR4 and CXCR7 Have Distinct Functions in Regulating Interneuron Migration

CXCL12/CXCR4 signaling is critical for cortical interneuron migration and their final laminar distribution. No information is yet available on CXCR7, a newly defined CXCL12 receptor. Here we demonstrated that CXCR7 regulated interneuron migration autonomously, as well as nonautonomously through its...

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Bibliographic Details

Published in:	Neuron (Cambridge, Mass.) Mass.), 2011-01, Vol.69 (1), p.61-76
Main Authors:	Wang, Yanling, Li, Guangnan, Stanco, Amelia, Long, Jason E., Crawford, Dianna, Potter, Gregory B., Pleasure, Samuel J., Behrens, Timothy, Rubenstein, John L.R.
Format:	Article
Language:	eng
Subjects:	Animals Cell Movement - physiology Cells, Cultured Cerebral Cortex - cytology Chemokine CXCL12 - metabolism Chemokines Defects Gene expression Immunohistochemistry Interneurons - metabolism Interneurons - physiology Kinases Ligands MAP Kinase Signaling System - physiology Membrane filters Mice Mice, Knockout Receptors, CXCR - deficiency Receptors, CXCR - genetics Receptors, CXCR - metabolism Receptors, CXCR4 - deficiency Receptors, CXCR4 - genetics Receptors, CXCR4 - metabolism Rodents Signal Transduction - physiology Software Statistical analysis
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