Basal-Like Phenotype in a Breast Carcinoma Case Series from Sudan: Prevalence and Clinical/Pathological Correlations

Basal-like breast cancer, an aggressive subtype associated with high grade, poor prognosis, and younger age, is reported frequently in Africa. We analyzed the expression of the basal cytokeratins (CKs) 5/6 and 17 in a case series from Central Sudan and investigated correlations among basal CK status...

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Published in:Pathology Research International 2011-01, Vol.2011 (2011), p.1-10
Main Authors: Awadelkarim, Khalid Dafaallah, Arizzi, Carmelo, Elamin, Elgizouli Omer Musa, Hamad, Hussein M. A., De Blasio, Pasquale, Mekki, Salwa O., Osman, Ihsan, Biunno, Ida, Elwali, Nasr Eldin, Barberis, Massimo Costanzo, Mariani-Costantini, Renato
Format: Article
Language:English
Subjects:
Breast cancer
Cancer
Carcinoma
Care and treatment
Clinical pathology
Diagnosis
Identification and classification
Phenotype
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Summary:Basal-like breast cancer, an aggressive subtype associated with high grade, poor prognosis, and younger age, is reported frequently in Africa. We analyzed the expression of the basal cytokeratins (CKs) 5/6 and 17 in a case series from Central Sudan and investigated correlations among basal CK status, ER, PgR, and Her-2/neu, and individual/clinicopathological data. Of 113 primary breast cancers 26 (23%), 38 (34%), and 46 (41%) were, respectively, positive for CK5/6, CK17, and combined basal CKs (CK5/6 and/or CK17). Combined basal CK+ status was associated with higher grade (P
ISSN:2090-8091
2042-003X
2042-003X
DOI:10.4061/2011/806831