Evolutionary origins of oxygen sensing in animals

Oxygen is required for aerobic energy production but its levels have to be tightly regulated to avoid deleterious effects. Thus, animals have evolved mechanisms to monitor and respond to fluctuations in oxygen availability. Here, the evolution of the HIF system is discussed in light of a report that...

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Bibliographic Details
Published in:EMBO reports 2011-01, Vol.12 (1), p.3-4
Main Authors: Rytkönen, Kalle T, Storz, Jay F
Format: Article
Language:English
Subjects:
Animals
Biological Evolution
Evolutionary biology
Humans
Hypoxia-Inducible Factor 1 - metabolism
Oxygen
Oxygen - physiology
Procollagen-Proline Dioxygenase - metabolism
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Summary:Oxygen is required for aerobic energy production but its levels have to be tightly regulated to avoid deleterious effects. Thus, animals have evolved mechanisms to monitor and respond to fluctuations in oxygen availability. Here, the evolution of the HIF system is discussed in light of a report that reveals its presence in the simplest animal.
ISSN:1469-221X
1469-3178
DOI:10.1038/embor.2010.192