Increased serum HSP70 levels are associated with the duration of diabetes
The evolutionary conserved family of heat shock proteins (HSP) is responsible for protecting cells against different types of stress, including oxidative stress. Although the levels of HSPs can be readily measured in blood serum, the levels of HSP70 in patients with different durations of diabetes h...
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| Published in: | Cell stress & chaperones 2010-11, Vol.15 (6), p.959-964 |
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Increased serum HSP70 levels are associated with the duration of diabetes |
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Article |
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Nakhjavani, Manouchehr Morteza, Afsaneh Khajeali, Leila Esteghamati, Alireza Khalilzadeh, Omid Asgarani, Firouzeh Outeiro, Tiago F. |
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Adult Age Factors Biochemistry Biomedical and Life Sciences Biomedicine Blood Glucose - analysis Cancer Research Cell Biology Cohort Studies Diabetes Diabetes complications Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - complications Diabetic nephropathies Fasting Female Heat shock proteins HSP70 Heat-Shock Proteins - blood Humans Hypertension Hypertension - complications Immunology Insulin Male Middle Aged Neurosciences Original Paper Oxidative stress Time Factors Type 1 diabetes mellitus Type 2 diabetes mellitus |
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Cell stress & chaperones, 2010-11, Vol.15 (6), p.959-964 |
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The evolutionary conserved family of heat shock proteins (HSP) is responsible for protecting cells against different types of stress, including oxidative stress. Although the levels of HSPs can be readily measured in blood serum, the levels of HSP70 in patients with different durations of diabetes have not been studied before. We quantified serum HSP70 levels in a healthy control group (n=36) and two groups of type 2 diabetic patients, defined as newly diagnosed diabetes (n=36) and patients with diabetes duration of more than 5 years (n=37). The clinical characteristics and biochemical parameters were evaluated in the studied population. We found that serum HSP70 levels were significantly higher in patients with diabetes when compared with controls (p |
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ISSN: 1355-8145 |
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Although the levels of HSPs can be readily measured in blood serum, the levels of HSP70 in patients with different durations of diabetes have not been studied before. We quantified serum HSP70 levels in a healthy control group (n=36) and two groups of type 2 diabetic patients, defined as newly diagnosed diabetes (n=36) and patients with diabetes duration of more than 5 years (n=37). The clinical characteristics and biochemical parameters were evaluated in the studied population. We found that serum HSP70 levels were significantly higher in patients with diabetes when compared with controls (p<0.001) and it was higher in patients with disease for more than 5 years than in newly diagnosed patients (p<0.001). Serum HSP70 was inversely correlated with fasting blood sugar in patients with diabetes for more than 5 years (r=-0.500, p=0.002), positively correlated with the history of hypertension in newly diagnosed patients (p<0.001), and positively correlated with age in patients with diabetes (r=0.531, p=0.001). Serum level of HSP70 is significantly higher in patients with diabetes and correlates with the duration of disease. Higher HSP70 in prolonged diabetes versus newly diagnosed diabetes may be an indicator of metabolic derangement in the course of diabetes.</description><identifier>ISSN: 1355-8145</identifier><identifier>EISSN: 1466-1268</identifier><identifier>DOI: 10.1007/s12192-010-0204-z</identifier><identifier>PMID: 20496051</identifier><language>eng</language><publisher>Dordrecht: Springer</publisher><subject>Adult ; Age Factors ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Blood Glucose - analysis ; Cancer Research ; Cell Biology ; Cohort Studies ; Diabetes ; Diabetes complications ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - complications ; Diabetic nephropathies ; Fasting ; Female ; Heat shock proteins ; HSP70 Heat-Shock Proteins - blood ; Humans ; Hypertension ; Hypertension - complications ; Immunology ; Insulin ; Male ; Middle Aged ; Neurosciences ; Original Paper ; Oxidative stress ; Time Factors ; Type 1 diabetes mellitus ; Type 2 diabetes mellitus</subject><ispartof>Cell stress & chaperones, 2010-11, Vol.15 (6), p.959-964</ispartof><rights>2010 Cell Stress Society International</rights><rights>Cell Stress Society International 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c490t-c93033dfeb52f265e0ff8c205122c2a14228058e60cfa92061f2b5ddbb83b11a3</citedby><cites>FETCH-LOGICAL-c490t-c93033dfeb52f265e0ff8c205122c2a14228058e60cfa92061f2b5ddbb83b11a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/20799990$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/20799990$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,315,734,787,791,892,1655,27985,27986,41485,42554,51702,54176,54178,58942,59175</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20496051$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nakhjavani, Manouchehr</creatorcontrib><creatorcontrib>Morteza, Afsaneh</creatorcontrib><creatorcontrib>Khajeali, Leila</creatorcontrib><creatorcontrib>Esteghamati, Alireza</creatorcontrib><creatorcontrib>Khalilzadeh, Omid</creatorcontrib><creatorcontrib>Asgarani, Firouzeh</creatorcontrib><creatorcontrib>Outeiro, Tiago F.</creatorcontrib><title>Increased serum HSP70 levels are associated with the duration of diabetes</title><title>Cell stress & chaperones</title><addtitle>Cell Stress and Chaperones</addtitle><addtitle>Cell Stress Chaperones</addtitle><description>The evolutionary conserved family of heat shock proteins (HSP) is responsible for protecting cells against different types of stress, including oxidative stress. Although the levels of HSPs can be readily measured in blood serum, the levels of HSP70 in patients with different durations of diabetes have not been studied before. We quantified serum HSP70 levels in a healthy control group (n=36) and two groups of type 2 diabetic patients, defined as newly diagnosed diabetes (n=36) and patients with diabetes duration of more than 5 years (n=37). The clinical characteristics and biochemical parameters were evaluated in the studied population. We found that serum HSP70 levels were significantly higher in patients with diabetes when compared with controls (p<0.001) and it was higher in patients with disease for more than 5 years than in newly diagnosed patients (p<0.001). Serum HSP70 was inversely correlated with fasting blood sugar in patients with diabetes for more than 5 years (r=-0.500, p=0.002), positively correlated with the history of hypertension in newly diagnosed patients (p<0.001), and positively correlated with age in patients with diabetes (r=0.531, p=0.001). Serum level of HSP70 is significantly higher in patients with diabetes and correlates with the duration of disease. Higher HSP70 in prolonged diabetes versus newly diagnosed diabetes may be an indicator of metabolic derangement in the course of diabetes.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Blood Glucose - analysis</subject><subject>Cancer Research</subject><subject>Cell Biology</subject><subject>Cohort Studies</subject><subject>Diabetes</subject><subject>Diabetes complications</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Diabetic nephropathies</subject><subject>Fasting</subject><subject>Female</subject><subject>Heat shock proteins</subject><subject>HSP70 Heat-Shock Proteins - blood</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hypertension - complications</subject><subject>Immunology</subject><subject>Insulin</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neurosciences</subject><subject>Original Paper</subject><subject>Oxidative stress</subject><subject>Time Factors</subject><subject>Type 1 diabetes mellitus</subject><subject>Type 2 diabetes mellitus</subject><issn>1355-8145</issn><issn>1466-1268</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><recordid>eNp9kUFv1DAQhS0EoqXwAziALC6cAjN2nDgXpKoCulIlkICz5TjjblbZuNhOEf31eJVSCgd8saV57_MbPcaeI7xBgPZtQoGdqAChAgF1dfOAHWPdNBWKRj8sb6lUpbFWR-xJSjsonrbFx-yoiLsGFB6zzWZ2kWyigSeKy56ff_ncAp_omqbEbSRuUwputLkofox5y_OW-LBEm8cw8-D5MNqeMqWn7JG3U6Jnt_cJ-_bh_dez8-ri08fN2elF5eoOcuU6CVIOnnolvGgUgffaiRJGCCcs1kJoUJoacN52Ahr0olfD0Pda9ohWnrB3K_dq6fc0OJpztJO5iuPexp8m2NH8PZnHrbkM10aCqAu5AF7fAmL4vlDKZj8mR9NkZwpLMq3SWkoEVZSv_lHuwhLnsp3RWPIqLQ44XEUuhpQi-bsoCOZQk1lrMqUmc6jJ3BTPy_s73Dl-91IEYhWkMpovKf75-X_UF6tpl3KI96BtVw7IX6vJpxk</recordid><startdate>20101101</startdate><enddate>20101101</enddate><creator>Nakhjavani, Manouchehr</creator><creator>Morteza, Afsaneh</creator><creator>Khajeali, Leila</creator><creator>Esteghamati, Alireza</creator><creator>Khalilzadeh, Omid</creator><creator>Asgarani, Firouzeh</creator><creator>Outeiro, Tiago F.</creator><general>Springer</general><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0L</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20101101</creationdate><title>Increased serum HSP70 levels are associated with the duration of diabetes</title><author>Nakhjavani, Manouchehr ; Morteza, Afsaneh ; Khajeali, Leila ; Esteghamati, Alireza ; Khalilzadeh, Omid ; Asgarani, Firouzeh ; Outeiro, Tiago F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c490t-c93033dfeb52f265e0ff8c205122c2a14228058e60cfa92061f2b5ddbb83b11a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Blood Glucose - 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Although the levels of HSPs can be readily measured in blood serum, the levels of HSP70 in patients with different durations of diabetes have not been studied before. We quantified serum HSP70 levels in a healthy control group (n=36) and two groups of type 2 diabetic patients, defined as newly diagnosed diabetes (n=36) and patients with diabetes duration of more than 5 years (n=37). The clinical characteristics and biochemical parameters were evaluated in the studied population. We found that serum HSP70 levels were significantly higher in patients with diabetes when compared with controls (p<0.001) and it was higher in patients with disease for more than 5 years than in newly diagnosed patients (p<0.001). Serum HSP70 was inversely correlated with fasting blood sugar in patients with diabetes for more than 5 years (r=-0.500, p=0.002), positively correlated with the history of hypertension in newly diagnosed patients (p<0.001), and positively correlated with age in patients with diabetes (r=0.531, p=0.001). Serum level of HSP70 is significantly higher in patients with diabetes and correlates with the duration of disease. Higher HSP70 in prolonged diabetes versus newly diagnosed diabetes may be an indicator of metabolic derangement in the course of diabetes.</abstract><cop>Dordrecht</cop><pub>Springer</pub><pmid>20496051</pmid><doi>10.1007/s12192-010-0204-z</doi><oa>free_for_read</oa></addata></record> |