Increased serum HSP70 levels are associated with the duration of diabetes

Increased serum HSP70 levels are associated with the duration of diabetes

The evolutionary conserved family of heat shock proteins (HSP) is responsible for protecting cells against different types of stress, including oxidative stress. Although the levels of HSPs can be readily measured in blood serum, the levels of HSP70 in patients with different durations of diabetes h...

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Bibliographic Details
Published in:Cell stress & chaperones 2010-11, Vol.15 (6), p.959-964
Main Authors: Nakhjavani, Manouchehr, Morteza, Afsaneh, Khajeali, Leila, Esteghamati, Alireza, Khalilzadeh, Omid, Asgarani, Firouzeh, Outeiro, Tiago F.
Format: Article
Language:eng
Subjects:
Adult
Age Factors
Biochemistry
Biomedical and Life Sciences
Biomedicine
Blood Glucose - analysis
Cancer Research
Cell Biology
Cohort Studies
Diabetes
Diabetes complications
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - complications
Diabetic nephropathies
Fasting
Female
Heat shock proteins
HSP70 Heat-Shock Proteins - blood
Humans
Hypertension
Hypertension - complications
Immunology
Insulin
Male
Middle Aged
Neurosciences
Original Paper
Oxidative stress
Time Factors
Type 1 diabetes mellitus
Type 2 diabetes mellitus
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Summary:The evolutionary conserved family of heat shock proteins (HSP) is responsible for protecting cells against different types of stress, including oxidative stress. Although the levels of HSPs can be readily measured in blood serum, the levels of HSP70 in patients with different durations of diabetes have not been studied before. We quantified serum HSP70 levels in a healthy control group (n=36) and two groups of type 2 diabetic patients, defined as newly diagnosed diabetes (n=36) and patients with diabetes duration of more than 5 years (n=37). The clinical characteristics and biochemical parameters were evaluated in the studied population. We found that serum HSP70 levels were significantly higher in patients with diabetes when compared with controls (p
ISSN:1355-8145
1466-1268