Hepatitis B Virus (HBV) Infection and Recombination between HBV Genotypes D and E in Asymptomatic Blood Donors from Khartoum, Sudan

Sudan is a highly endemic area for hepatitis B virus (HBV), and >5% of blood donors are chronically infected. To examine potential strategies to improve HBV blood safety, 404 replacement donor samples previously screened for HBV surface antigen (HBsAg) were tested for antibody to HBV core (anti-H...

Full description

Saved in:
Bibliographic Details
Published in:Journal of Clinical Microbiology 2011-01, Vol.49 (1), p.298-306
Main Authors: Mahgoub, Shaza, Candotti, Daniel, El Ekiaby, Magdy, Allain, Jean-Pierre
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biological and medical sciences
Blood Donors
Carrier State - virology
DNA, Viral - blood
DNA, Viral - chemistry
DNA, Viral - genetics
Female
Fundamental and applied biological sciences. Psychology
Genotype
Hepatitis B - virology
Hepatitis B Antibodies - blood
Hepatitis B Surface Antigens - blood
Hepatitis B virus
Hepatitis B virus - classification
Hepatitis B virus - genetics
Hepatitis B virus - isolation & purification
Human viral diseases
Humans
Infectious diseases
Male
Medical sciences
Microbiology
Middle Aged
Miscellaneous
Molecular Sequence Data
Recombination, Genetic
Sequence Analysis, DNA
Sudan
Viral diseases
Viral hepatitis
Virology
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Sudan is a highly endemic area for hepatitis B virus (HBV), and >5% of blood donors are chronically infected. To examine potential strategies to improve HBV blood safety, 404 replacement donor samples previously screened for HBV surface antigen (HBsAg) were tested for antibody to HBV core (anti-HBc), anti-surface antigen (anti-HBs), and HBV DNA. Of 145 anti-HBc-containing samples (36%) identified, 16 retested were HBsAg positive (11%). Anti-HBs was detected in 43/77 (56%) anti-HBc-reactive samples. Six samples were HBsAg⁻/anti-HBc⁺/anti-HBs⁺ and contained HBV DNA, meeting the definition of occult HBV infection (OBI). OBIs had low HBV DNA loads (
ISSN:0095-1137
1098-660X
DOI:10.1128/JCM.00867-10