lncRNAdb: a reference database for long noncoding RNAs

Large numbers of long RNAs with little or no protein-coding potential [long noncoding RNAs (lncRNAs)] are being identified in eukaryotes. In parallel, increasing data describing the expression profiles, molecular features and functions of individual lncRNAs in a variety of systems are accumulating....

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Bibliographic Details
Published in:Nucleic acids research 2011-01, Vol.39 (Database issue), p.D146-D151
Main Authors: Amaral, Paulo P, Clark, Michael B, Gascoigne, Dennis K, Dinger, Marcel E, Mattick, John S
Format: Article
Language:English
Subjects:
Conserved sequence
Data processing
Databases, Nucleic Acid
Disease - genetics
Genomes
genomics
Host-Pathogen Interactions
Humans
mRNA
RNA, Untranslated - chemistry
RNA, Untranslated - metabolism
RNA, Untranslated - physiology
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Summary:Large numbers of long RNAs with little or no protein-coding potential [long noncoding RNAs (lncRNAs)] are being identified in eukaryotes. In parallel, increasing data describing the expression profiles, molecular features and functions of individual lncRNAs in a variety of systems are accumulating. To enable the systematic compilation and updating of this information, we have developed a database (lncRNAdb) containing a comprehensive list of lncRNAs that have been shown to have, or to be associated with, biological functions in eukaryotes, as well as messenger RNAs that have regulatory roles. Each entry contains referenced information about the RNA, including sequences, structural information, genomic context, expression, subcellular localization, conservation, functional evidence and other relevant information. lncRNAdb can be searched by querying published RNA names and aliases, sequences, species and associated protein-coding genes, as well as terms contained in the annotations, such as the tissues in which the transcripts are expressed and associated diseases. In addition, lncRNAdb is linked to the UCSC Genome Browser for visualization and Noncoding RNA Expression Database (NRED) for expression information from a variety of sources. lncRNAdb provides a platform for the ongoing collation of the literature pertaining to lncRNAs and their association with other genomic elements. lncRNAdb can be accessed at: http://www.lncrnadb.org/.
ISSN:0305-1048
1362-4962
1362-4962
DOI:10.1093/nar/gkq1138