Gender differences in the association of C-reactive protein with coronary artery calcium in Type-2 diabetes

Summary Objectives  Plasma C‐reactive protein (CRP) is associated with cardiovascular disease (CVD), but effects may vary by gender and degree of CVD risk. Whether CRP has value as a CVD risk marker in type‐2 diabetes (T2DM) is unclear. We examined whether CRP has gender differences in association w...

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Published in:Clinical endocrinology (Oxford) 2011-01, Vol.74 (1), p.44-50
Main Authors: Qasim, Atif N., Budharaju, Venkata, Mehta, Nehal N., St Clair, Caitlin, Farouk, Samira, Braunstein, Seth, Schutta, Mark, Iqbal, Nayyar, Rader, Daniel J., Reilly, Muredach P.
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
C-Reactive Protein - metabolism
Coronary Artery Disease - metabolism
Cross-Sectional Studies
Diabetes Mellitus, Type 2 - metabolism
Diabetes. Impaired glucose tolerance
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Female
Fundamental and applied biological sciences. Psychology
Humans
Male
Medical sciences
Middle Aged
Sex Factors
Vertebrates: endocrinology
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Summary:Summary Objectives  Plasma C‐reactive protein (CRP) is associated with cardiovascular disease (CVD), but effects may vary by gender and degree of CVD risk. Whether CRP has value as a CVD risk marker in type‐2 diabetes (T2DM) is unclear. We examined whether CRP has gender differences in association with coronary artery calcium (CAC) in diabetic and nondiabetic samples without clinical CVD. Methods  We performed cross‐sectional analyses of gender influence on CRP association with CAC in the Penn Diabetes Heart Study (N = 1299 with T2DM), the Study of Inherited Risk of Coronary Atherosclerosis (N = 860 nondiabetic subjects) and a combined sample. Results  Female gender was associated with higher plasma CRP in diabetic and nondiabetic samples after adjustment for covariates. There was a strong interaction by gender in the association of CRP with CAC (interaction P 
ISSN:0300-0664
1365-2265
DOI:10.1111/j.1365-2265.2010.03879.x