Improving the accuracy of pre-operative survival prediction in renal cell carcinoma with C-reactive protein

Validated objective biomarkers are needed for patients with renal cell carcinoma (RCC) to guide patient management and define high-risk populations for follow-up or for therapeutic purposes. Patients undergoing nephrectomy for RCC (n=286 all stages, 84% with conventional clear cell type) were includ...

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Bibliographic Details
Published in:British journal of cancer 2010-11, Vol.103 (11), p.1649-1656
Main Authors: JAGDEV, Spk, GREGORY, W, VASUDEV, N. S, HARNDEN, P, SIM, S, THOMPSON, D, GARTLEDGE, J, SELBY, P. J, BANKS, R. E
Format: Article
Language:English
Subjects:
Accuracy
Adult
Aged
Aged, 80 and over
Algorithms
Biological and medical sciences
Biomarkers
C-Reactive Protein - analysis
Cancer research
Carcinoma, Renal Cell - blood
Carcinoma, Renal Cell - mortality
Clinical Study
Female
Hematology
Hospitals
Humans
Kidney cancer
Kidney Neoplasms - blood
Kidney Neoplasms - mortality
Kidneys
Male
Medical prognosis
Medical research
Medical sciences
Metastasis
Middle Aged
Multivariate analysis
Nephrology. Urinary tract diseases
Patients
Polyethylene glycol
Prognosis
Proportional Hazards Models
Proteins
Tumors
Tumors of the urinary system
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Summary:Validated objective biomarkers are needed for patients with renal cell carcinoma (RCC) to guide patient management and define high-risk populations for follow-up or for therapeutic purposes. Patients undergoing nephrectomy for RCC (n=286 all stages, 84% with conventional clear cell type) were included with a median duration follow-up of 5 years. The prognostic significance of pre-operative haematological and biochemical variables, including C-reactive protein (CRP) values were examined and whether they added additional information to a recently published pre-operative scoring system was determined. C-reactive protein was the most significant predictor of overall survival (OS; χ(2)=50.9, P15 mg l(-1) was 72% (95% CI 65-78%) and 33% (95% CI 23-44%), respectively. Similar results were seen for cancer-specific survival (CSS) and disease-free survival. On multivariate analysis, CRP remained highly significant for CSS (χ(2)=17.3, P
ISSN:0007-0920
1532-1827
DOI:10.1038/sj.bjc.6605973