Histamine receptors and cancer pharmacology

Considerable evidence has been collected indicating that histamine can modulate proliferation of different normal and malignant cells. High histamine biosynthesis and content together with histamine receptors have been reported in different human neoplasias including melanoma, colon and breast cance...

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Bibliographic Details
Published in:British journal of pharmacology 2010-10, Vol.161 (4), p.755-767
Main Authors: Medina, Vanina A., Rivera, Elena S.
Format: Article
Language:English
Subjects:
Animals
anticancer drugs
Antineoplastic Agents - pharmacology
Biological and medical sciences
breast cancer
Cancer
cancer pharmacology
Cell Proliferation
colon cancer
Dermatology
Drug Delivery Systems
Drug Design
Gastroenterology. Liver. Pancreas. Abdomen
Gynecology. Andrology. Obstetrics
Histamine
Histamine - metabolism
histamine H4 receptor
histamine H4 receptor ligands
Humans
malignancy
Mammary gland diseases
Medical research
Medical sciences
melanoma
Neoplasms - drug therapy
Neoplasms - physiopathology
Pharmacology. Drug treatments
Receptors, G-Protein-Coupled - drug effects
Receptors, G-Protein-Coupled - metabolism
Receptors, Histamine - drug effects
Receptors, Histamine - metabolism
Receptors, Histamine H4
Reviews
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Tumors
Tumors of the skin and soft tissue. Premalignant lesions
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Summary:Considerable evidence has been collected indicating that histamine can modulate proliferation of different normal and malignant cells. High histamine biosynthesis and content together with histamine receptors have been reported in different human neoplasias including melanoma, colon and breast cancer, as well as in experimental tumours in which histamine has been postulated to behave as an important paracrine and autocrine regulator of proliferation. The discovery of the human histamine H4 receptor in different tissues has contributed to our understanding of histamine role in numerous physiological and pathological conditions revealing novel functions for histamine and opening new perspectives in histamine pharmacology research. In the present review we aimed to briefly summarize current knowledge on histamine and histamine receptor involvement in cancer before focusing on some recent evidence supporting the novel role of histamine H4 receptor in cancer progression representing a promising molecular target and avenue for cancer drug development. LINKED ARTICLES BJP has previously published a Histamine themed issue (2009). To view this issue visit http://dx.doi.org/10.1111/bph.2009.157.issue‐1
ISSN:0007-1188
1476-5381
DOI:10.1111/j.1476-5381.2010.00961.x