The NPC-Transporter, A Ghost in the Machine

Yeast FG nucleoporins are intrinsically disordered proteins that contain cohesive molten globular regions and repulsive extended-coil regions. When placed along the central axis of the NPC, FG nups may self-assemble to create a novel transport channel that provides a series of docking sites for kary...

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Bibliographic Details
Published in:Structure (London) 2010-10, Vol.18 (10), p.1230-1232
Main Author: Akey, Christopher W.
Format: Article
Language:English
Subjects:
Channels
Cohesion
Docking
Ghosts
Proteins
Transport
Yeast
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Summary:Yeast FG nucleoporins are intrinsically disordered proteins that contain cohesive molten globular regions and repulsive extended-coil regions. When placed along the central axis of the NPC, FG nups may self-assemble to create a novel transport channel that provides a series of docking sites for karyopherin-cargo complexes ( Yamada et al., 2010).
ISSN:0969-2126
1878-4186
DOI:10.1016/j.str.2010.09.005