Rev-erb-alpha: an integrator of circadian rhythms and metabolism

The endogenous circadian clock ensures daily rhythms in diverse behavioral and physiological processes, including locomotor activity and sleep/wake cycles, but also food intake patterns. Circadian rhythms are generated by an internal clock system, which synchronizes these daily variations to the day...

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Bibliographic Details
Published in:Journal of applied physiology (1985) 2009-12, Vol.107 (6), p.1972-1980
Main Authors: Duez, Hélène, Staels, Bart
Format: Article
Language:English
Subjects:
Animals
Biochemistry, Molecular Biology
Biological Clocks
Biological Clocks - physiology
Circadian Rhythm
Circadian Rhythm - physiology
CLOCK Proteins
CLOCK Proteins - physiology
Humans
Life Sciences
Metabolic Networks and Pathways
Metabolic Networks and Pathways - physiology
Metabolic Syndrome - physiopathology
Metabolic Syndrome X
Nuclear Receptor Subfamily 1, Group D, Member 1
Nuclear Receptor Subfamily 1, Group D, Member 1 - physiology
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Summary:The endogenous circadian clock ensures daily rhythms in diverse behavioral and physiological processes, including locomotor activity and sleep/wake cycles, but also food intake patterns. Circadian rhythms are generated by an internal clock system, which synchronizes these daily variations to the day/night alternance. In addition, circadian oscillations may be reset by the time of food availability in peripheral metabolic organs. Circadian rhythms are seen in many metabolic pathways (glucose and lipid metabolism, etc.) and endocrine secretions (insulin, etc.). As a consequence, misalignment of the internal timing system vs. environmental zeitgebers (light, for instance), as experienced during jetlag or shift work, may result in disruption of physiological cycles of fuel utilization or energy storage. A large body of evidence from both human and animal studies now points to a relationship between circadian disorders and altered metabolic response, suggesting that circadian and metabolic regulatory networks are tightly connected. After a review of the current understanding of the molecular circadian core clock, we will discuss the hypothesis that clock genes themselves link the core molecular clock and metabolic regulatory networks. We propose that the nuclear receptor and core clock component Rev-erb-alpha behaves as a gatekeeper to timely coordinate the circadian metabolic response.
ISSN:8750-7587
1522-1601
DOI:10.1152/japplphysiol.00570.2009