O-GlcNAc signaling: a metabolic link between diabetes and cancer?

O-linked β-N-acetylglucosamine (O-GlcNAc) is a sugar attachment to serine or threonine hydroxyl moieties on nuclear and cytoplasmic proteins. In many ways, O-GlcNAcylation is similar to phosphorylation because both post-translational modifications cycle rapidly in response to internal or environment...

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Bibliographic Details
Published in:Trends in biochemical sciences (Amsterdam. Regular ed.) 2010-10, Vol.35 (10), p.547-555
Main Authors: Slawson, C., Copeland, R.J., Hart, G.W.
Format: Article
Language:English
Subjects:
Acetylglucosamine - metabolism
Animals
Diabetes Mellitus - metabolism
Hexosamines - biosynthesis
Humans
Insulin - metabolism
Neoplasms - metabolism
Signal Transduction
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Summary:O-linked β-N-acetylglucosamine (O-GlcNAc) is a sugar attachment to serine or threonine hydroxyl moieties on nuclear and cytoplasmic proteins. In many ways, O-GlcNAcylation is similar to phosphorylation because both post-translational modifications cycle rapidly in response to internal or environmental cues. O-GlcNAcylated proteins are involved in transcription, translation, cytoskeletal assembly, signal transduction, and many other cellular functions. O-GlcNAc signaling is intertwined with cellular metabolism; indeed, the donor sugar for O-GlcNAcylation (UDP-GlcNAc) is synthesized from glucose, glutamine, and UTP via the hexosamine biosynthetic pathway. Emerging research indicates that O-GlcNAc signaling and its crosstalk with phosphorylation are altered in metabolic diseases, such as diabetes and cancer.
ISSN:0968-0004
1362-4326
DOI:10.1016/j.tibs.2010.04.005