Gut inflammation provides a respiratory electron acceptor for Salmonella

Salmonella enterica serotype Typhimurium (S. Typhimurium) causes acute gut inflammation by using its virulence factors to invade the intestinal epithelium and survive in mucosal macrophages. The inflammatory response enhances the transmission success of S. Typhimurium by promoting its outgrowth in t...

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Bibliographic Details
Published in:	Nature (London) 2010-09, Vol.467 (7314), p.426-429
Main Authors:	Bäumler, Andreas J, Winter, Sebastian E, Thiennimitr, Parameth, Winter, Maria G, Butler, Brian P, Huseby, Douglas L, Crawford, Robert W, Russell, Joseph M, Bevins, Charles L, Adams, L. Garry, Tsolis, Renée M, Roth, John R
Format:	Article
Language:	eng
Subjects:	Animals Bacteria Bacteriology Biological and medical sciences Cell Respiration Colitis - metabolism Colitis - microbiology Colorectal diseases Development and progression Electron Transport Electrons Female Fundamental and applied biological sciences. Psychology Gastrointestinal diseases Gastrointestinal Tract - metabolism Gastrointestinal Tract - microbiology Gastrointestinal Tract - pathology Genes Health aspects Inflammation Inflammation - metabolism Inflammation - microbiology Inflammation - pathology Intestinal Mucosa - metabolism Intestinal Mucosa - microbiology Intestinal Mucosa - pathology Mice Mice, Inbred C57BL Microbiology Molecular and cellular biology Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains Physiological aspects Proteins Reactive oxygen species Reactive Oxygen Species - metabolism Rodents Salmonella Salmonella enterica Salmonella typhimurium Salmonella typhimurium - growth & development Salmonella typhimurium - metabolism Tetrathionic Acid - metabolism Thiosulfates - metabolism
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Summary:	Salmonella enterica serotype Typhimurium (S. Typhimurium) causes acute gut inflammation by using its virulence factors to invade the intestinal epithelium and survive in mucosal macrophages. The inflammatory response enhances the transmission success of S. Typhimurium by promoting its outgrowth in the gut lumen through unknown mechanisms. Here we show that reactive oxygen species generated during inflammation react with endogenous, luminal sulphur compounds (thiosulphate) to form a new respiratory electron acceptor, tetrathionate. The genes conferring the ability to use tetrathionate as an electron acceptor produce a growth advantage for S. Typhimurium over the competing microbiota in the lumen of the inflamed gut. We conclude that S. Typhimurium virulence factors induce host-driven production of a new electron acceptor that allows the pathogen to use respiration to compete with fermenting gut microbes. Thus the ability to trigger intestinal inflammation is crucial for the biology of this diarrhoeal pathogen.
ISSN:	0028-0836 1476-4687