Administration of a soluble activin type IIB receptor promotes skeletal muscle growth independent of fiber type

This is the first report that inhibition of negative regulators of skeletal muscle by a soluble form of activin type IIB receptor (ACE-031) increases muscle mass independent of fiber-type expression. This finding is distinct from the effects of selective pharmacological inhibition of myostatin (GDF-...

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Bibliographic Details
Published in:Journal of applied physiology (1985) 2010-09, Vol.109 (3), p.635-642
Main Authors: CADENA, Samuel M, TOMKINSON, Kathleen N, MONNELL, Travis E, SPAITS, Matthew S, KUMAR, Ravindra, UNDERWOOD, Kathryn W, PEARSALL, R. Scott, LACHEY, Jennifer L
Format: Article
Language:English
Subjects:
Activin Receptors, Type II - administration & dosage
Activin Receptors, Type II - genetics
Animals
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation
Humans
Hypertrophy
Immunoglobulin Fc Fragments - genetics
Immunoglobulin G - genetics
Male
Mice
Mice, Inbred C57BL
Muscle Development - drug effects
Muscle Fibers, Fast-Twitch - drug effects
Muscle Fibers, Fast-Twitch - metabolism
Muscle Fibers, Slow-Twitch - drug effects
Muscle Fibers, Slow-Twitch - metabolism
Muscle, Skeletal - drug effects
Muscle, Skeletal - growth & development
Muscle, Skeletal - metabolism
Muscular dystrophy
Musculoskeletal system
Myosin Heavy Chains - genetics
Myosin Heavy Chains - metabolism
Myostatin - antagonists & inhibitors
Organ Size
Pharmacology
Protein Isoforms
Proteins
Recombinant Fusion Proteins - administration & dosage
RNA, Messenger - metabolism
Statins
Time Factors
Weight Gain
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Summary:This is the first report that inhibition of negative regulators of skeletal muscle by a soluble form of activin type IIB receptor (ACE-031) increases muscle mass independent of fiber-type expression. This finding is distinct from the effects of selective pharmacological inhibition of myostatin (GDF-8), which predominantly targets type II fibers. In our study 8-wk-old C57BL/6 mice were treated with ACE-031 or vehicle control for 28 days. By the end of treatment, mean body weight of the ACE-031 group was 16% greater than that of the control group, and wet weights of soleus, plantaris, gastrocnemius, and extensor digitorum longus muscles increased by 33, 44, 46 and 26%, respectively (P
ISSN:8750-7587
1522-1601
1522-1601
DOI:10.1152/japplphysiol.00866.2009