A case–control study on sequence variations in the enhancer II/core promoter/precore and X genes of hepatitis B virus in patients with hepatocellular carcinoma

Purpose To evaluate the sequence variations in the enhancer II (EnhII)/basal core promotor (BCP)/precore (PC) and X genes of hepatitis B virus (HBV) in Thai patients with hepatocellular carcinoma (HCC) by conducting a cross-sectional case–control study. Methods As much as 60 patients with HCC and 60...

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Published in:Hepatology international 2010-09, Vol.4 (3), p.577-584
Main Authors: Tangkijvanich, Pisit, Sa-nguanmoo, Pattaratida, Mahachai, Varocha, Theamboonlers, Apiradee, Poovorawan, Yong
Format: Article
Language:English
Subjects:
Colorectal Surgery
Genes
Hepatitis
Hepatitis B virus
Hepatology
Liver cancer
Medicine
Medicine & Public Health
Mutation
Original
Original Article
Surgery
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Summary:Purpose To evaluate the sequence variations in the enhancer II (EnhII)/basal core promotor (BCP)/precore (PC) and X genes of hepatitis B virus (HBV) in Thai patients with hepatocellular carcinoma (HCC) by conducting a cross-sectional case–control study. Methods As much as 60 patients with HCC and 60 patients without HCC, who were matched for sex, age, hepatitis B e antigen (HBeAg) status, and HBV genotype, were included. Viral mutations in the EnhII/BCP/PC and X regions were characterized by direct sequencing in serum samples. Results The prevalence of T1753C/A, A1762T/G1764A and G1899A mutations were significantly higher in the HCC group compared to the non-HCC group (43.3 vs. 23.3%, P  = 0.02; 88.3 vs. 53.0%, P  
ISSN:1936-0533
1936-0541
DOI:10.1007/s12072-010-9197-z