The biological and toxicological activity of gases and vapors

A large amount of data on the biological and toxicological activity of gases and vapors has been collected from the literature. Processes include sensory irritation thresholds, the Alarie mouse test, inhalation anesthesia, etc. It is shown that a single equation using only five descriptors (properti...

Full description

Saved in:
Bibliographic Details
Published in:Toxicology in vitro 2010-03, Vol.24 (2), p.357-362
Main Authors: Abraham, Michael H., Sánchez-Moreno, Ricardo, Gil-Lostes, Javier, Acree, William E., Enrique Cometto-Muñiz, J., Cain, William S.
Format: Article
Language:English
Subjects:
Anesthesia
Animals
Eye Diseases - chemically induced
Eye irritation thresholds
Gases - toxicity
Humans
Linear free energy relationship
Models, Biological
Nasal pungency threshold
Odor detection threshold
Quantitative structure-activity relationship
Upper respiratory tract irritation in mice
Volatile compound
Volatile Organic Compounds - toxicity
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A large amount of data on the biological and toxicological activity of gases and vapors has been collected from the literature. Processes include sensory irritation thresholds, the Alarie mouse test, inhalation anesthesia, etc. It is shown that a single equation using only five descriptors (properties of the gases and vapors) plus a set of indicator variables for the given processes can correlate 643 biological and non-lethal toxicological activities of ‘non-reactive’ compounds with a standard deviation of 0.36 log unit. The equation is scaled to sensory irritation thresholds obtained by the procedure of Cometto-Muñiz, and Cain provides a general equation for the prediction of sensory irritation thresholds in man. It is suggested that differences in biological/toxicological activity arise primarily from transport from the gas phase to a receptor phase or area, except for odor detection thresholds where interaction with a receptor(s) is important.
ISSN:0887-2333
1879-3177
DOI:10.1016/j.tiv.2009.11.009