Coordinated Increased Expression of Cyclooxygenase2 and Nuclear Factor κB Is a Steady Feature of Urinary Bladder Carcinogenesis

Objectives. The inescapable relationship between chronic inflammation and carcinogenesis has long been established. Our objective was to investigate COX-2 and NF-κB immunohistochemical expression in a large series of normal epithelium and bladder carcinomas. Methods. Immunohistochemical methodology...

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Bibliographic Details
Published in:Advances in Urology 2010-01, Vol.2010 (2010), p.1-8
Main Authors: Sotiropoulou-Bonikou, Georgia, Kontos, Stylianos, Kominea, Athina, Melachrinou, Maria, Balampani, Eleni, Bonikos, Dionysis
Format: Article
Language:English
Subjects:
Bladder cancer
Care and treatment
Cyclooxygenases
Development and progression
Gene expression
Genetic aspects
Physiological aspects
Risk factors
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Summary:Objectives. The inescapable relationship between chronic inflammation and carcinogenesis has long been established. Our objective was to investigate COX-2 and NF-κB immunohistochemical expression in a large series of normal epithelium and bladder carcinomas. Methods. Immunohistochemical methodology was performed on formalin-fixed, paraffin-embedded sections from urinary bladder carcinomas of 140 patients (94 males and 46 females with bladder carcinomas). Results. COX-2 expression is increased in the cytoplasm of bladder cells, during loss of cell differentiation (rs=0.61, P-value
ISSN:1687-6369
1687-6377
DOI:10.1155/2010/871356