Microemboli may link spreading depression, migraine aura, and patent foramen ovale

Objective Patent foramen ovale and pulmonary arteriovenous shunts are associated with serious complications such as cerebral emboli, stroke, and migraine with aura. The pathophysiological mechanisms that link these conditions are unknown. We aimed to establish a mechanism linking microembolization t...

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Bibliographic Details
Published in:Annals of neurology 2010-02, Vol.67 (2), p.221-229
Main Authors: Nozari, Ala, Dilekoz, Ergin, Sukhotinsky, Inna, Stein, Thor, Eikermann-Haerter, Katharina, Liu, Christina, Wang, Yumei, Frosch, Matthew P., Waeber, Christian, Ayata, Cenk, Moskowitz, Michael A.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cerebrovascular Circulation - physiology
Cortical Spreading Depression - physiology
Disease Models, Animal
Electroencephalography - methods
Embolism - complications
Foramen Ovale, Patent - etiology
Functional Laterality - physiology
Magnetic Resonance Imaging - methods
Medical sciences
Mice
Mice, Inbred C57BL
Microcirculation - physiology
Migraine with Aura - etiology
Neurologic Examination - methods
Neurology
Vascular diseases and vascular malformations of the nervous system
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Summary:Objective Patent foramen ovale and pulmonary arteriovenous shunts are associated with serious complications such as cerebral emboli, stroke, and migraine with aura. The pathophysiological mechanisms that link these conditions are unknown. We aimed to establish a mechanism linking microembolization to migraine aura in an experimental animal model. Methods We introduced particulate or air microemboli into the carotid circulation in mice to determine whether transient microvascular occlusion, insufficient to cause infarcts, triggered cortical spreading depression (CSD), a propagating slow depolarization that underlies migraine aura. Results Air microemboli reliably triggered CSD without causing infarction. Polystyrene microspheres (10μm) or cholesterol crystals (
ISSN:0364-5134
1531-8249
DOI:10.1002/ana.21871