Mitochondrial DNA alterations and reduced mitochondrial function in aging

Oxidative damage to mitochondrial DNA increases with aging. This damage has the potential to affect mitochondrial DNA replication and transcription which could alter the abundance or functionality of mitochondrial proteins. This review describes mitochondrial DNA alterations and changes in mitochond...

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Bibliographic Details
Published in:Mechanisms of ageing and development 2010-07, Vol.131 (7), p.451-462
Main Authors: Hebert, Sadie L., Lanza, Ian R., Nair, K. Sreekumaran
Format: Article
Language:English
Subjects:
Age Factors
Aging
Aging - genetics
Aging - metabolism
Animals
DNA Damage
DNA, Mitochondrial - metabolism
Energy Metabolism - genetics
Gene Expression Regulation
Humans
Mice
Mitochondria
Mitochondria - metabolism
Mitochondrial DNA
Mutation
Oxidative Stress
Reactive Oxygen Species - metabolism
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Summary:Oxidative damage to mitochondrial DNA increases with aging. This damage has the potential to affect mitochondrial DNA replication and transcription which could alter the abundance or functionality of mitochondrial proteins. This review describes mitochondrial DNA alterations and changes in mitochondrial function that occur with aging. Age-related alterations in mitochondrial DNA as a possible contributor to the reduction in mitochondrial function are discussed.
ISSN:0047-6374
1872-6216
DOI:10.1016/j.mad.2010.03.007