Consanguinity and increased risk for schizophrenia in Egypt

Abstract Background Consanguinity has been suggested as a risk factor for psychoses in some Middle Eastern countries, but adequate control data are unavailable. Our recent studies in Egypt have shown elevated parental consanguinity rates among patients with bipolar I disorder (BP1), compared with co...

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Bibliographic Details
Published in:Schizophrenia research 2010-07, Vol.120 (1), p.108-112
Main Authors: Mansour, Hader, Fathi, Warda, Klei, Lambertus, Wood, Joel, Chowdari, Kodavali, Watson, Annie, Eissa, Ahmed, Elassy, Mai, Ali, Ibtihal, Salah, Hala, Yassin, Amal, Tobar, Salwa, El-Boraie, Hala, Gaafar, Hanan, Ibrahim, Nahed E, Kandil, Kareem, El-Bahaei, Wafaa, El-Boraie, Osama, Alatrouny, Mohamed, El-Chennawi, Farha, Devlin, Bernie, Nimgaonkar, Vishwajit L
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Association
Biological and medical sciences
Case-Control Studies
Consanguinity
DNA
DNA Mutational Analysis - methods
Egypt - epidemiology
Female
Genetic
Humans
Inbreeding
Male
Medical sciences
Microsatellite Repeats - genetics
Odds Ratio
Polymorphism, Genetic - genetics
Psychiatry
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychoses
Schizophrenia
Schizophrenia - epidemiology
Schizophrenia - genetics
Self Disclosure
Young Adult
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Summary:Abstract Background Consanguinity has been suggested as a risk factor for psychoses in some Middle Eastern countries, but adequate control data are unavailable. Our recent studies in Egypt have shown elevated parental consanguinity rates among patients with bipolar I disorder (BP1), compared with controls. We have now extended our analyses to schizophrenia (SZ) in the same population. Methods A case–control study was conducted at Mansoura University Hospital, Mansoura, Egypt (SZ, n = 75; controls, n = 126, and their available parents). The prevalence of consanguinity was estimated from family history data (‘self report’), followed by DNA analysis using short tandem repeat polymorphisms (STRPs, n = 63) (‘DNA-based’ rates). Results Self-reported consanguinity was significantly elevated among the patients (SZ: 46.6%, controls: 19.8%, OR 3.53, 95% CI 1.88, 6.64; p = 0.000058, 1 d.f.). These differences were confirmed using DNA-based estimates for coefficients of inbreeding (inbreeding coefficients as means ± standard error, cases: 0.058 ± 0.007, controls: 0.022 ± 0.003). Conclusions Consanguinity rates are signifcantly elevated among Egyptian SZ patients in the Nile delta region. The associations are similar to those observed with BP1 in our earlier study. If replicated, the substantial risk associated with consanguinity raises public health concerns. They may also pave the way for gene mapping studies.
ISSN:0920-9964
1573-2509
DOI:10.1016/j.schres.2010.03.026