The ANG-(1-7)/ACE2/mas axis in the regulation of nephron function

The study of experimental hypertension and the development of drugs with selective inhibitory effects on the enzymes and receptors constituting the components of the circulating and tissue renin-angiotensin systems have led to newer concepts of how this system participates in both physiology and pat...

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Bibliographic Details
Published in:American journal of physiology. Renal physiology 2010-06, Vol.298 (6), p.F1297-F1305
Main Authors: Ferrario, Carlos M, Varagic, Jasmina
Format: Article
Language:English
Subjects:
ACE inhibitors
Angiotensin I - metabolism
Angiotensin II - metabolism
Animals
Antihypertensive Agents - therapeutic use
Blood Pressure
Humans
Hypertension
Hypertension - drug therapy
Hypertension - enzymology
Hypertension - physiopathology
Kidney diseases
Nephrology
Nephrons - drug effects
Nephrons - enzymology
Nephrons - physiopathology
Peptide Fragments - metabolism
Peptidyl-Dipeptidase A - metabolism
Physiology
Proto-Oncogene Proteins - metabolism
Receptors, G-Protein-Coupled - metabolism
Reviews
Signal Transduction - drug effects
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Summary:The study of experimental hypertension and the development of drugs with selective inhibitory effects on the enzymes and receptors constituting the components of the circulating and tissue renin-angiotensin systems have led to newer concepts of how this system participates in both physiology and pathology. Over the last decade, a renewed emphasis on understanding the role of angiotensin-(1-7) and angiotensin-converting enzyme 2 in the regulation of blood pressure and renal function has shed new light on the complexity of the mechanisms by which these components of the renin angiotensin system act in the heart and in the kidneys to exert a negative regulatory influence on angiotensin converting enzyme and angiotensin II. The vasodepressor axis composed of angiotensin-(1-7)/angiotensin-converting enzyme 2/mas receptor emerges as a site for therapeutic interventions within the renin-angiotensin system. This review summarizes the evolving knowledge of the counterregulatory arm of the renin-angiotensin system in the control of nephron function and renal disease.
ISSN:1931-857X
1522-1466
DOI:10.1152/ajprenal.00110.2010