Molecular characterisation of side population cells with cancer stem cell-like characteristics in small-cell lung cancer

Side population (SP) fraction cells, identified by efflux of Hoechst dye, are present in virtually all normal and malignant tissues. The relationship between SP cells, drug resistance and cancer stem cells is poorly understood. Small-cell lung cancer (SCLC) is a highly aggressive human tumour with a...

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Bibliographic Details
Published in:British journal of cancer 2010-05, Vol.102 (11), p.1636-1644
Main Authors: SALCIDO, C. D, LAROCHELLE, A, TAYLOR, B. J, DUNBAR, C. E, VARTICOVSKI, L
Format: Article
Language:English
Subjects:
Animals
Antigens, Surface - analysis
Antigens, Surface - genetics
Antigens, Surface - metabolism
Biological and medical sciences
Biomarkers, Tumor - analysis
Biomarkers, Tumor - genetics
Biomarkers, Tumor - metabolism
Cell Line, Tumor
Cell Separation
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Humans
Lung cancer
Lung Neoplasms - genetics
Lung Neoplasms - pathology
Male
Medical sciences
Mice
Mice, Inbred NOD
Mice, SCID
Molecular Diagnostics
Neoplastic Stem Cells - metabolism
Neoplastic Stem Cells - pathology
Pneumology
Small Cell Lung Carcinoma - genetics
Small Cell Lung Carcinoma - pathology
Tumors
Tumors of the respiratory system and mediastinum
Validation Studies as Topic
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Description
Summary:Side population (SP) fraction cells, identified by efflux of Hoechst dye, are present in virtually all normal and malignant tissues. The relationship between SP cells, drug resistance and cancer stem cells is poorly understood. Small-cell lung cancer (SCLC) is a highly aggressive human tumour with a 5-year survival rate of
ISSN:0007-0920
1532-1827
DOI:10.1038/sj.bjc.6605668