Endothelial dysfunction in diabetes mellitus: Molecular mechanisms and clinical implications

Cardiovascular disease is a major complication of diabetes mellitus, and improved strategies for prevention and treatment are needed. Endothelial dysfunction contributes to the pathogenesis and clinical expression of atherosclerosis in diabetes mellitus. This article reviews the evidence linking end...

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Bibliographic Details
Published in:Reviews in endocrine & metabolic disorders 2010-03, Vol.11 (1), p.61-74
Main Authors: Tabit, Corey E, Chung, William B, Hamburg, Naomi M, Vita, Joseph A
Format: Article
Language:English
Subjects:
Animals
Atherosclerosis - etiology
Atherosclerosis - physiopathology
Cardiovascular Diseases - etiology
Diabetes
Diabetes Mellitus - physiopathology
Endocrinology
Endothelium, Vascular - physiopathology
Humans
Inflammation - etiology
Inflammation - physiopathology
Insulin Resistance - physiology
Internal Medicine
Medicine
Medicine & Public Health
Mitochondria - physiology
Nitric Oxide - biosynthesis
Nitric Oxide - physiology
Nitric Oxide Synthase Type III - physiology
Oxidative Stress
Phosphatidylinositol 3-Kinases - metabolism
Protein Kinase C - metabolism
Protein Kinase C beta
Signal Transduction - physiology
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Summary:Cardiovascular disease is a major complication of diabetes mellitus, and improved strategies for prevention and treatment are needed. Endothelial dysfunction contributes to the pathogenesis and clinical expression of atherosclerosis in diabetes mellitus. This article reviews the evidence linking endothelial dysfunction to human diabetes mellitus and experimental studies that investigated the responsible mechanisms. We then discuss the implications of these studies for current management and for new approaches for the prevention and treatment of cardiovascular disease in patients with diabetes mellitus.
ISSN:1389-9155
1573-2606
DOI:10.1007/s11154-010-9134-4