Rapid access to morphinones: removal of 4,5-ether bridge with Pd-catalyzed triflate reduction

A new synthetic method for the removal of the 4,5-bridged ether moiety of several opioids has been developed. This process offers a faster, simpler synthetic route to obtain the morphinone scaffold in high yields without the need for protection of the ketone moiety.

Saved in:
Bibliographic Details
Published in:Tetrahedron letters 2010-04, Vol.51 (17), p.2359-2361
Main Authors: Hupp, Christopher D., Neumeyer, John L.
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A new synthetic method for the removal of the 4,5-bridged ether moiety of several opioids has been developed. This process offers a faster, simpler synthetic route to obtain the morphinone scaffold in high yields without the need for protection of the ketone moiety.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2010.02.146