SARS transmission in Vietnam outside of the health-care setting

To evaluate the risk of transmission of SARS coronavirus outside of the health-care setting, close household and community contacts of laboratory-confirmed SARS cases were identified and followed up for clinical and laboratory evidence of SARS infection. Individual- and household-level risk factors...

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Bibliographic Details
Published in:Epidemiology & Infection 2007-04, Vol.135 (3), p.392-401
Main Authors: TUAN, P. A., HORBY, P., DINH, P. N., MAI, L. T. Q., ZAMBON, M., SHAH, J., HUY, V. Q., BLOOM, S., GOPAL, R., COMER, J., PLANT, A.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Child
Child, Preschool
Consent
Coronaviruses
Data transmission
Disease Outbreaks
Disease transmission
Epidemics
Epidemiology
Estimates
Female
Fundamental and applied biological sciences. Psychology
Health surveillance
Hospitals
Households
Humans
Infant
Infections
Infectious diseases
Investigations
Laboratories
Male
Microbiology
Middle Aged
Questionnaires
Reactivity
Risk Factors
SARS
SARS coronavirus
SARS virus
Severe acute respiratory syndrome
Severe Acute Respiratory Syndrome - epidemiology
Severe Acute Respiratory Syndrome - etiology
Severe Acute Respiratory Syndrome - transmission
Symptoms
Vietnam - epidemiology
Citations: Items that cite this one
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Summary:To evaluate the risk of transmission of SARS coronavirus outside of the health-care setting, close household and community contacts of laboratory-confirmed SARS cases were identified and followed up for clinical and laboratory evidence of SARS infection. Individual- and household-level risk factors for transmission were investigated. Nine persons with serological evidence of SARS infection were identified amongst 212 close contacts of 45 laboratory- confirmed SARS cases (secondary attack rate 4·2%, 95% CI 1·5–7). In this cohort, the average number of secondary infections caused by a single infectious case was 0·2. Two community contacts with laboratory evidence of SARS coronavirus infection had mild or sub-clinical infection, representing 3% (2/65) of Vietnamese SARS cases. There was no evidence of transmission of infection before symptom onset. Physically caring for a symptomatic laboratory-confirmed SARS case was the only independent risk factor for SARS transmission (OR 5·78, 95% CI 1·23–24·24).
ISSN:0950-2688
1469-4409
DOI:10.1017/S0950268806006996