Parenting Moderates a Genetic Vulnerability Factor in Longitudinal Increases in Youths' Substance Use

The authors used a longitudinal, prospective design to investigate a moderation effect in the association between a genetic vulnerability factor, a variable nucleotide repeat polymorphism in the promoter region of 5HTT (5-HTTLPR), and increases in youths' substance use. The primary study hypoth...

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Bibliographic Details
Published in:Journal of consulting and clinical psychology 2009-02, Vol.77 (1), p.1-11
Main Authors: Brody, Gene H, Beach, Steven R. H, Philibert, Robert A, Chen, Yi-fu, Lei, Man-Kit, Murry, Velma McBride, Brown, Anita C
Format: Article
Language:English
Subjects:
Addictive behaviors
Adolescent
Adolescents
Adult and adolescent clinical studies
African Americans
Alleles
Biological and medical sciences
Black People
Child
Child of Impaired Parents - statistics & numerical data
Child Rearing
Children & youth
Drug Abuse
Drug addiction
Drug use
Female
Genetic Predisposition to Disease
Genetics
Georgia
Human
Humans
Longitudinal Studies
Male
Medical sciences
Moderation
Mothers
Parent Child Relationship
Parenting
Parenting Skills
Parenting Styles
Parents & parenting
Polymorphism
Polymorphism, Genetic - genetics
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Risk
Rural Areas
Serotonin Plasma Membrane Transport Proteins - genetics
Studies
Substance Abuse
Substance-Related Disorders - epidemiology
Substance-Related Disorders - genetics
Time Factors
Vulnerability
Young people
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Summary:The authors used a longitudinal, prospective design to investigate a moderation effect in the association between a genetic vulnerability factor, a variable nucleotide repeat polymorphism in the promoter region of 5HTT (5-HTTLPR), and increases in youths' substance use. The primary study hypothesis predicted that involved-supportive parenting would attenuate the link between the 5-HTTLPR polymorphism and longitudinal increases in substance use. African American youths residing in rural Georgia ( N = 253, mean age = 11.5 years) provided 4 waves of data on their own substance use; the mothers of the youths provided data on their own parenting practices. Genetic data were obtained from youths via saliva samples. Latent growth curve modeling indicated that 5-HTTLPR status (presence of 1 or 2 copies of the s allele) was linked with increases in substance use over time; however, this association was greatly reduced when youths received high levels of involved-supportive parenting. This study demonstrates that parenting processes have the potential to ameliorate genetic risk.
ISSN:0022-006X
1939-2117
DOI:10.1037/a0012996