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Dry powdered aerosols of diatrizoic acid nanoparticle agglomerates as a lung contrast agent
Aerosolized contrast agents may improve the resolution of biomedical imaging modalities and enable more accurate diagnosis of lung diseases. Many iodinated compounds, such as diatrizoic acid, have been shown to be safe and useful for radiographic examination of the airways. Formulations of such comp...
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| Published in: | International journal of pharmaceutics 2010-05, Vol.391 (1), p.305-312 |
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| cites | cdi_FETCH-LOGICAL-c496t-c2055986d7fbb662c8a2f4646912ee1739c7612d66ba00ac767f3d07b0aceb953 |
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| container_title | International journal of pharmaceutics |
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| creator | El-Gendy, Nashwa Aillon, Kristin L. Berkland, Cory |
| description | Aerosolized contrast agents may improve the resolution of biomedical imaging modalities and enable more accurate diagnosis of lung diseases. Many iodinated compounds, such as diatrizoic acid, have been shown to be safe and useful for radiographic examination of the airways. Formulations of such compounds must be improved in order to allow imaging of the smallest airways. Here, diatrizoic acid nanoparticle agglomerates were created by assembling nanoparticles into inhalable microparticles that may augment deposition in the lung periphery. Nanoparticle agglomerates were fully characterized and safety was determined
in vivo. After dry powder insufflation to rats, no acute alveolar tissue damage was observed 2
h post-dose. Diatrizoic acid nanoparticle agglomerates possess the characteristics of an efficient and safe inhalable lung contrast agent. |
| doi_str_mv | 10.1016/j.ijpharm.2010.03.009 |
| format | article |
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in vivo. After dry powder insufflation to rats, no acute alveolar tissue damage was observed 2
h post-dose. Diatrizoic acid nanoparticle agglomerates possess the characteristics of an efficient and safe inhalable lung contrast agent.</description><subject>Administration, Inhalation</subject><subject>Aerosols</subject><subject>Aerosols - administration & dosage</subject><subject>Aerosols - chemical synthesis</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Chemistry, Pharmaceutical - methods</subject><subject>Contrast Media - administration & dosage</subject><subject>Contrast Media - adverse effects</subject><subject>Contrast medium</subject><subject>CT imaging</subject><subject>Diatrizoate Meglumine - administration & dosage</subject><subject>Diatrizoate Meglumine - adverse effects</subject><subject>Diatrizoate Meglumine - chemistry</subject><subject>Diatrizoic acid</subject><subject>Drug Carriers - administration & dosage</subject><subject>Drug Carriers - chemical synthesis</subject><subject>Dry powder</subject><subject>Female</subject><subject>General pharmacology</subject><subject>Lung - anatomy & histology</subject><subject>Medical sciences</subject><subject>Nanoparticles - administration & dosage</subject><subject>Nanoparticles - chemistry</subject><subject>Nanoparticles - ultrastructure</subject><subject>Particle Size</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>Powders - chemistry</subject><subject>Pulmonary delivery</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Solubility</subject><subject>Surface Properties</subject><issn>0378-5173</issn><issn>1873-3476</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><recordid>eNqFkU1v1DAQhi0EotvCTwD5gjhl8UdiJxcQKhQqVeoFThysiT3ZeuXEwc4WlV-PV7sUeqplyWPPM-NX8xLyirM1Z1y92679dr6BNK4FK29MrhnrnpAVb7WsZK3VU7JiUrdVw7U8Iac5bxljSnD5nJwIJnjdKbYiPz6lOzrHXw4TOgqYYo4h0zhQ52FJ_nf0loL1jk4wxRnS4m1ACptNiCMmWDBTKJuG3bShNk5LgryUPE7LC_JsgJDx5fE8I98vPn87_1pdXX-5PP94VdmiYamsYE3Ttcrpoe-VErYFMdSqVh0XiEV9Z7XiwinVA2NQLnqQjum-xNh3jTwj7w99510_orO4FxHMnPwI6c5E8OZhZvI3ZhNvjWibrqzS4O2xQYo_d5gXM_psMQSYMO6y0VJ2oqjhhWwOpC2DygmH-184M3tfzNYcfTF7XwyTpvhS6l7_L_G-6q8RBXhzBCBbCEOCyfr8jxO6kapuC_fhwGEZ6K3HZLL1OFl0PqFdjIv-ESl_AByssJs</recordid><startdate>20100531</startdate><enddate>20100531</enddate><creator>El-Gendy, Nashwa</creator><creator>Aillon, Kristin L.</creator><creator>Berkland, Cory</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20100531</creationdate><title>Dry powdered aerosols of diatrizoic acid nanoparticle agglomerates as a lung contrast agent</title><author>El-Gendy, Nashwa ; Aillon, Kristin L. ; Berkland, Cory</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c496t-c2055986d7fbb662c8a2f4646912ee1739c7612d66ba00ac767f3d07b0aceb953</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Administration, Inhalation</topic><topic>Aerosols</topic><topic>Aerosols - administration & dosage</topic><topic>Aerosols - chemical synthesis</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Chemistry, Pharmaceutical - methods</topic><topic>Contrast Media - administration & dosage</topic><topic>Contrast Media - adverse effects</topic><topic>Contrast medium</topic><topic>CT imaging</topic><topic>Diatrizoate Meglumine - administration & dosage</topic><topic>Diatrizoate Meglumine - adverse effects</topic><topic>Diatrizoate Meglumine - chemistry</topic><topic>Diatrizoic acid</topic><topic>Drug Carriers - administration & dosage</topic><topic>Drug Carriers - chemical synthesis</topic><topic>Dry powder</topic><topic>Female</topic><topic>General pharmacology</topic><topic>Lung - anatomy & histology</topic><topic>Medical sciences</topic><topic>Nanoparticles - administration & dosage</topic><topic>Nanoparticles - chemistry</topic><topic>Nanoparticles - ultrastructure</topic><topic>Particle Size</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>Powders - chemistry</topic><topic>Pulmonary delivery</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Solubility</topic><topic>Surface Properties</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>El-Gendy, Nashwa</creatorcontrib><creatorcontrib>Aillon, Kristin L.</creatorcontrib><creatorcontrib>Berkland, Cory</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of pharmaceutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>El-Gendy, Nashwa</au><au>Aillon, Kristin L.</au><au>Berkland, Cory</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dry powdered aerosols of diatrizoic acid nanoparticle agglomerates as a lung contrast agent</atitle><jtitle>International journal of pharmaceutics</jtitle><addtitle>Int J Pharm</addtitle><date>2010-05-31</date><risdate>2010</risdate><volume>391</volume><issue>1</issue><spage>305</spage><epage>312</epage><pages>305-312</pages><issn>0378-5173</issn><eissn>1873-3476</eissn><coden>IJPHDE</coden><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Aerosolized contrast agents may improve the resolution of biomedical imaging modalities and enable more accurate diagnosis of lung diseases. Many iodinated compounds, such as diatrizoic acid, have been shown to be safe and useful for radiographic examination of the airways. Formulations of such compounds must be improved in order to allow imaging of the smallest airways. Here, diatrizoic acid nanoparticle agglomerates were created by assembling nanoparticles into inhalable microparticles that may augment deposition in the lung periphery. Nanoparticle agglomerates were fully characterized and safety was determined
in vivo. After dry powder insufflation to rats, no acute alveolar tissue damage was observed 2
h post-dose. Diatrizoic acid nanoparticle agglomerates possess the characteristics of an efficient and safe inhalable lung contrast agent.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>20214960</pmid><doi>10.1016/j.ijpharm.2010.03.009</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Administration, Inhalation Aerosols Aerosols - administration & dosage Aerosols - chemical synthesis Animals Biological and medical sciences Chemistry, Pharmaceutical - methods Contrast Media - administration & dosage Contrast Media - adverse effects Contrast medium CT imaging Diatrizoate Meglumine - administration & dosage Diatrizoate Meglumine - adverse effects Diatrizoate Meglumine - chemistry Diatrizoic acid Drug Carriers - administration & dosage Drug Carriers - chemical synthesis Dry powder Female General pharmacology Lung - anatomy & histology Medical sciences Nanoparticles - administration & dosage Nanoparticles - chemistry Nanoparticles - ultrastructure Particle Size Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Powders - chemistry Pulmonary delivery Rats Rats, Sprague-Dawley Solubility Surface Properties |
| title | Dry powdered aerosols of diatrizoic acid nanoparticle agglomerates as a lung contrast agent |
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