Dry powdered aerosols of diatrizoic acid nanoparticle agglomerates as a lung contrast agent

Aerosolized contrast agents may improve the resolution of biomedical imaging modalities and enable more accurate diagnosis of lung diseases. Many iodinated compounds, such as diatrizoic acid, have been shown to be safe and useful for radiographic examination of the airways. Formulations of such comp...

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Bibliographic Details
Published in:International journal of pharmaceutics 2010-05, Vol.391 (1), p.305-312
Main Authors: El-Gendy, Nashwa, Aillon, Kristin L., Berkland, Cory
Format: Article
Language:English
Subjects:
Administration, Inhalation
Aerosols
Aerosols - administration & dosage
Aerosols - chemical synthesis
Animals
Biological and medical sciences
Chemistry, Pharmaceutical - methods
Contrast Media - administration & dosage
Contrast Media - adverse effects
Contrast medium
CT imaging
Diatrizoate Meglumine - administration & dosage
Diatrizoate Meglumine - adverse effects
Diatrizoate Meglumine - chemistry
Diatrizoic acid
Drug Carriers - administration & dosage
Drug Carriers - chemical synthesis
Dry powder
Female
General pharmacology
Lung - anatomy & histology
Medical sciences
Nanoparticles - administration & dosage
Nanoparticles - chemistry
Nanoparticles - ultrastructure
Particle Size
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Powders - chemistry
Pulmonary delivery
Rats
Rats, Sprague-Dawley
Solubility
Surface Properties
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Summary:Aerosolized contrast agents may improve the resolution of biomedical imaging modalities and enable more accurate diagnosis of lung diseases. Many iodinated compounds, such as diatrizoic acid, have been shown to be safe and useful for radiographic examination of the airways. Formulations of such compounds must be improved in order to allow imaging of the smallest airways. Here, diatrizoic acid nanoparticle agglomerates were created by assembling nanoparticles into inhalable microparticles that may augment deposition in the lung periphery. Nanoparticle agglomerates were fully characterized and safety was determined in vivo. After dry powder insufflation to rats, no acute alveolar tissue damage was observed 2 h post-dose. Diatrizoic acid nanoparticle agglomerates possess the characteristics of an efficient and safe inhalable lung contrast agent.
ISSN:0378-5173
1873-3476
DOI:10.1016/j.ijpharm.2010.03.009