A Histone-Fold Complex and FANCM Form a Conserved DNA-Remodeling Complex to Maintain Genome Stability

FANCM remodels branched DNA structures and plays essential roles in the cellular response to DNA replication stress. Here, we show that FANCM forms a conserved DNA-remodeling complex with a histone-fold heterodimer, MHF. We find that MHF stimulates DNA binding and replication fork remodeling by FANC...

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Bibliographic Details

Published in:	Molecular cell 2010-03, Vol.37 (6), p.865-878
Main Authors:	Yan, Zhijiang, Delannoy, Mathieu, Ling, Chen, Daee, Danielle, Osman, Fekret, Muniandy, Parameswary A., Shen, Xi, Oostra, Anneke B., Du, Hansen, Steltenpool, Jurgen, Lin, Ti, Schuster, Beatrice, Décaillet, Chantal, Stasiak, Andrzej, Stasiak, Alicja Z., Stone, Stacie, Hoatlin, Maureen E., Schindler, Detlev, Woodcock, Christopher L., Joenje, Hans, Sen, Ranjan, de Winter, Johan P., Li, Lei, Seidman, Michael M., Whitby, Matthew C., Myung, Kyungjae, Constantinou, Angelos, Wang, Weidong
Format:	Article
Language:	eng
Subjects:	Amino Acid Sequence Animals Cell Line Chickens DNA DNA - genetics DNA - metabolism DNA Damage DNA Helicases - chemistry DNA Helicases - genetics DNA Helicases - metabolism DNA Replication DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Evolution, Molecular Fanconi Anemia Complementation Group Proteins Genomic Instability Histones - metabolism Humans Molecular Sequence Data Protein Binding Protein Folding Protein Multimerization PROTEINS Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Schizosaccharomyces - genetics Schizosaccharomyces - metabolism Sequence Alignment Sister Chromatid Exchange
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