Patterns of divergence in the vCXCL and vGPCR gene clusters in primate cytomegalovirus genomes

Abstract Primate cytomegalovirus (CMV) genomes contain tandemly repeated gene clusters putatively encoding divergent CXC chemokine ligand-like proteins (vCXCLs) and G protein-coupled receptor-like proteins (vGPCRs). In human, chimpanzee and rhesus CMVs, respectively, the vCXCL cluster contains two,...

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Bibliographic Details
Published in:Virology (New York, N.Y.) N.Y.), 2009-12, Vol.395 (1), p.21-32
Main Authors: Alcendor, Donald J, Zong, Jianchao, Dolan, Aidan, Gatherer, Derek, Davison, Andrew J, Hayward, Gary S
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Baboon cytomegalovirus
Cell Line
Chemokine
Chemokine receptor
Chemokines, CXC - genetics
Cytomegalovirus
Cytomegalovirus - genetics
Diversity
Evolution
Evolution, Molecular
Gene Duplication
Genes, Viral
Genome, Viral
Green monkey cytomegalovirus
GRO-α
Human cytomegalovirus
Humans
Infectious Disease
Molecular Sequence Data
Multigene Family
Owl monkey cytomegalovirus
Pan troglodytes
Phylogeny
Primates
Primates - virology
Receptors, G-Protein-Coupled - genetics
Rhesus cytomegalovirus
Sequence Alignment
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Summary:Abstract Primate cytomegalovirus (CMV) genomes contain tandemly repeated gene clusters putatively encoding divergent CXC chemokine ligand-like proteins (vCXCLs) and G protein-coupled receptor-like proteins (vGPCRs). In human, chimpanzee and rhesus CMVs, respectively, the vCXCL cluster contains two, three and six genes, and the vGPCR cluster contains two, two and five genes. We report that (i) green monkey CMV strains fall into two groups, containing either eight and five genes or seven and six genes in the respective clusters, and (ii) owl monkey CMV has two and zero genes. Phylogenetic analysis suggested that the vCXCL cluster evolved from a CXCL chemokine gene (probably GRO-α) that was captured in an incompletely spliced form by an ancestor of Old and New World primate CMVs, and that the vGPCR cluster evolved from a GPCR gene captured by an Old World primate CMV. Both clusters appear to have evolved via complex duplication and deletion events.
ISSN:0042-6822
1096-0341
DOI:10.1016/j.virol.2009.09.002