Surface Feature-Guided Mapping of Cerebral Metabolic Changes in Cognitively Normal and Mildly Impaired Elderly

Purpose The aim of this study was to investigate the longitudinal positron emission tomography (PET) metabolic changes in the elderly. Procedures Nineteen nondemented subjects (mean Mini-Mental Status Examination 29.4 ± 0.7 SD) underwent two detailed neuropsychological evaluations and resting 2-deox...

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Bibliographic Details
Published in:Molecular imaging and biology 2010-04, Vol.12 (2), p.218-224
Main Authors: Apostolova, Liana G., Thompson, Paul M., Rogers, Steve A., Dinov, Ivo D., Zoumalan, Charleen, Steiner, Calen A., Siu, Erin, Green, Amity E., Small, Gary W., Toga, Arthur W., Cummings, Jeffrey L., Phelps, Michael E., Silverman, Daniel H.
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Alzheimer's disease (AD)
BASIC BIOLOGICAL SCIENCES
Brain - metabolism
Brain - pathology
Brain Mapping - methods
Cognition
Cognition Disorders - diagnostic imaging
Cognition Disorders - genetics
Cognition Disorders - metabolism
Cognitive decline
Demography
Female
Fluorodeoxyglucose F18
Humans
Imaging
Male
Medicine
Medicine & Public Health
Middle Aged
Mild cognitive impairment (MCI)
Positron emission tomography (PET)
Positron-Emission Tomography
Radiology
Research Article
Surface Properties
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Summary:Purpose The aim of this study was to investigate the longitudinal positron emission tomography (PET) metabolic changes in the elderly. Procedures Nineteen nondemented subjects (mean Mini-Mental Status Examination 29.4 ± 0.7 SD) underwent two detailed neuropsychological evaluations and resting 2-deoxy-2-[F-18]fluoro- d -glucose (FDG)-PET scan (interval 21.7 ± 3.7 months), baseline structural 3T magnetic resonance (MR) imaging, and apolipoprotein E4 genotyping. Cortical PET metabolic changes were analyzed in 3-D using the cortical pattern matching technique. Results Baseline vs. follow-up whole-group comparison revealed significant metabolic decline bilaterally in the posterior temporal, parietal, and occipital lobes and the left lateral frontal cortex. The declining group demonstrated 10–15% decline in bilateral posterior cingulate/precuneus, posterior temporal, parietal, and occipital cortices. The cognitively stable group showed 2.5–5% similarly distributed decline. ApoE4-positive individuals underwent 5–15% metabolic decline in the posterior association cortices. Conclusions Using 3-D surface-based MR-guided FDG-PET mapping, significant metabolic changes were seen in five posterior and the left lateral frontal regions. The changes were more pronounced for the declining relative to the cognitively stable group.
ISSN:1536-1632
1860-2002
DOI:10.1007/s11307-009-0247-7