Nuclear phosphoinositides: a signaling enigma wrapped in a compartmental conundrum

While the presence of phosphoinositides in the nuclei of eukaryotes and the identity of the enzymes responsible for their metabolism have been known for some time, their functions in the nucleus are only now emerging. This is illustrated by the recent identification of effectors for nuclear phosphoi...

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Bibliographic Details
Published in:Trends in cell biology 2010-01, Vol.20 (1), p.25-35
Main Authors: Barlow, Christy A, Laishram, Rakesh S, Anderson, Richard A
Format: Article
Language:English
Subjects:
Animals
Cell Nucleus - metabolism
Gene Expression Regulation
Humans
Pathology
Phosphatidylinositols - metabolism
Protein Kinases - metabolism
Signal Transduction
Stress, Physiological
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Summary:While the presence of phosphoinositides in the nuclei of eukaryotes and the identity of the enzymes responsible for their metabolism have been known for some time, their functions in the nucleus are only now emerging. This is illustrated by the recent identification of effectors for nuclear phosphoinositides. Like the cytosolic phosphoinositide signaling pathway, nuclear phosphatidylinositol 4,5-bisphosphate (PI4,5P2 ) is at the center of the pathway and acts both as a messenger and as a precursor for many additional messengers. Here, recent advances in the understanding of nuclear phosphoinositide signaling and its functions are reviewed with an emphasis on PI4,5P2 and its role in gene expression. The compartmentalization of nuclear phosphoinositide phosphates (PIP n ) remains a mystery, but emerging evidence suggests that phosphoinositides occupy several functionally distinct compartments.
ISSN:0962-8924
1879-3088
DOI:10.1016/j.tcb.2009.09.009