DRYGIN: a database of quantitative genetic interaction networks in yeast

Genetic interactions are highly informative for deciphering the underlying functional principles that govern how genes control cell processes. Recent developments in Synthetic Genetic Array (SGA) analysis enable the mapping of quantitative genetic interactions on a genome-wide scale. To facilitate a...

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Bibliographic Details
Published in:Nucleic acids research 2010-01, Vol.38 (Database issue), p.D502-D507
Main Authors: Koh, Judice L.Y, Ding, Huiming, Costanzo, Michael, Baryshnikova, Anastasia, Toufighi, Kiana, Bader, Gary D, Myers, Chad L, Andrews, Brenda J, Boone, Charles
Format: Article
Language:English
Subjects:
Computational Biology - methods
Computational Biology - trends
Databases, Genetic
Databases, Nucleic Acid
Databases, Protein
Fungal Proteins - genetics
Genes, Fungal
Genome, Fungal
Information Storage and Retrieval - methods
Internet
Models, Genetic
Protein Interaction Mapping
Protein Structure, Tertiary
Software
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Summary:Genetic interactions are highly informative for deciphering the underlying functional principles that govern how genes control cell processes. Recent developments in Synthetic Genetic Array (SGA) analysis enable the mapping of quantitative genetic interactions on a genome-wide scale. To facilitate access to this resource, which will ultimately represent a complete genetic interaction network for a eukaryotic cell, we developed DRYGIN (Data Repository of Yeast Genetic Interactions)--a web database system that aims at providing a central platform for yeast genetic network analysis and visualization. In addition to providing an interface for searching the SGA genetic interactions, DRYGIN also integrates other data sources, in order to associate the genetic interactions with pathway information, protein complexes, other binary genetic and physical interactions, and Gene Ontology functional annotation. DRYGIN version 1.0 currently holds more than 5.4 million measurements of genetic interacting pairs involving ~4500 genes, and is available at http://drygin.ccbr.utoronto.ca
ISSN:0305-1048
1362-4962
DOI:10.1093/nar/gkp820