The association between symptomatic, severe hypoglycaemia and mortality in type 2 diabetes: retrospective epidemiological analysis of the ACCORD study

Objective To determine whether there is a link between hypoglycaemia and mortality among participants in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial.Design Retrospective epidemiological analysis of data from the ACCORD trial.Setting Diabetes clinics, research clinics, and pr...

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Bibliographic Details
Published in:BMJ 2010-01, Vol.340 (7738), p.137-137
Main Authors: Bonds, Denise E, Miller, Michael E, Bergenstal, Richard M, Buse, John B, Byington, Robert P, Cutler, Jeff A, Dudl, R James, Ismail-Beigi, Faramarz, Kimel, Angela R, Hoogwerf, Byron, Horowitz, Karen R, Savage, Peter J, Seaquist, Elizabeth R, Simmons, Debra L, Sivitz, William I, Speril-Hillen, Joann M, Sweeney, Mary Ellen
Format: Article
Language:English
Subjects:
Aged
Antihypertensive Agents - adverse effects
Attention deficit disorder
Blood glucose
Blood pressure
Cardiovascular disease
Cardiovascular diseases
Clinics
Coma
Death
Diabetes
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - drug therapy
Diabetes Mellitus, Type 2 - mortality
Diabetic Angiopathies - blood
Diabetic Angiopathies - drug therapy
Diabetic Angiopathies - mortality
Drugs: Cardiovascular System
Epidemiologic Studies
Female
General Practice / Family Medicine
Glucose
Glucose monitoring
Glycated Hemoglobin A - metabolism
Health care industry
Health hazards
Heart attacks
Hemoglobin
Humans
Hyperlipidemias - mortality
Hyperlipidemias - prevention & control
Hypertension - mortality
Hypertension - prevention & control
Hypoglycaemia
Hypoglycemia
Hypoglycemia - blood
Hypoglycemia - chemically induced
Hypoglycemia - mortality
Hypoglycemic Agents - adverse effects
Hypolipidemic Agents - adverse effects
Hypotheses
Male
Metabolic Disorders
Middle Aged
Mortality
Randomized Controlled Trials as Topic
Retrospective Studies
Risk Factors
Screening (Epidemiology)
Screening (Public Health)
Type 2 diabetes mellitus
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Description
Summary:Objective To determine whether there is a link between hypoglycaemia and mortality among participants in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial.Design Retrospective epidemiological analysis of data from the ACCORD trial.Setting Diabetes clinics, research clinics, and primary care clinics.Participants Patients were eligible for the ACCORD study if they had type 2 diabetes, a glycated haemoglobin (haemoglobin A1C) concentration of 7.5% or more during screening, and were aged 40-79 years with established cardiovascular disease or 55-79 years with evidence of subclinical disease or two additional cardiovascular risk factors. Intervention Intensive (haemoglobin A1C
ISSN:0959-8138
0959-535X
1468-5833
1756-1833
DOI:10.1136/bmj.b4909