Follow-Up of Mild Cognitive Impairment and Related Disorders over Four Years in Adults in Their Sixties: The PATH Through Life Study

Aims: The study aimed to estimate incidence rates of mild cognitive impairment and related disorders, and conversion to dementia. Methods: The data are drawn from the PATH Through Life Study. Baseline assessment in 2001–2002 included 2,551 participants 60–64 years old with 2,222 participating in a 4...

Full description

Saved in:
Bibliographic Details
Published in:Dementia and geriatric cognitive disorders 2008-01, Vol.26 (3), p.226-233
Main Authors: Anstey, Kaarin J., Cherbuin, Nicolas, Christensen, Helen, Burns, Richard, Reglade-Meslin, Chantal, Salim, Agus, Kumar, Rajeev, Jorm, Anthony F., Sachdev, Perminder
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cognition Disorders - diagnosis
Cognition Disorders - epidemiology
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Dementia - diagnosis
Dementia - epidemiology
Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes
Early Diagnosis
Female
Follow-Up Studies
Humans
Incidence
Longitudinal Studies
Male
Medical sciences
Middle Aged
Nervous system (semeiology, syndromes)
Neurology
Neuropsychological Tests
Original
Original Research Article
Predictive Value of Tests
Prevalence
Severity of Illness Index
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Aims: The study aimed to estimate incidence rates of mild cognitive impairment and related disorders, and conversion to dementia. Methods: The data are drawn from the PATH Through Life Study. Baseline assessment in 2001–2002 included 2,551 participants 60–64 years old with 2,222 participating in a 4-year follow-up. Those screened positive with a cognitive assessment received clinical assessment for diagnoses of mild cognitive disorders (MCD) or dementia using established clinical criteria. Prevalence and incidence rates for the cohort were estimated with predictive regression models. Results: Annual incidence of dementia was 0.25%. Prevalence of mild cognitive impairment was 4.2%, age-associated memory impairment was 2.4%, age-associated cognitive decline was 7.6%, mild neurocognitive disorders occurred in 12.9% and other cognitive disorders in 7.3%. Prevalence of any diagnosis of any MCD (Any-MCD) was 29.5% and the annual incidence rate for Any-MCD was 5.7%. Agreement for specific diagnoses between waves 1 and 2 was fair to poor (0–47.0%), but agreement for Any-MCD over 4 years was 89.0%. Conclusion: MCD diagnoses do not predict dementia at a 4-year follow-up in young-old adults. Prevalence rates for MCD vary greatly depending on the criteria and time of assessment.
ISSN:1420-8008
1421-9824
DOI:10.1159/000154646